CD22
Gene Ontology Molecular Function
Gene Ontology Cellular Component
AP2A1
Gene Ontology Biological Process
- Golgi to endosome transport [NAS]
- antigen processing and presentation of exogenous peptide antigen via MHC class II [TAS]
- axon guidance [TAS]
- clathrin-mediated endocytosis [TAS]
- endocytosis [NAS]
- epidermal growth factor receptor signaling pathway [TAS]
- intracellular protein transport [NAS]
- negative regulation of epidermal growth factor receptor signaling pathway [TAS]
- negative regulation of hyaluronan biosynthetic process [IDA, IMP]
- neurotrophin TRK receptor signaling pathway [TAS]
- regulation of defense response to virus by virus [TAS]
- synaptic transmission [TAS]
- viral process [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
The B cell coreceptor CD22 associates with AP50, a clathrin-coated pit adapter protein, via tyrosine-dependent interaction.
The B cell coreceptor CD22 plays an important role in regulating signal transduction via the B cell Ag receptor. Studies have shown that surface expression of CD22 can be modulated in response to binding of ligand (i.e., mAb). Thus, it is possible that alterations in the level of CD22 expression following binding of natural ligand(s) may affect its ability to ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID