Publication

Cyclophilin J limits inflammation through the blockage of ubiquitin chain sensing.

Sheng C, Yao C, Wang Z, Chen H, Zhao Y, Xu D, Huang H, Huang W, Chen S

Maintaining innate immune homeostasis is important for individual health. Npl4 zinc finger (NZF) domain-mediated ubiquitin chain sensing is reported to function in the nuclear factor-kappa B (NF-κB) signal pathway, but the regulatory mechanism remains elusive. Here we show that cyclophilin J (CYPJ), a member of the peptidylprolyl isomerase family, is induced by inflammation. CYPJ interacts with the NZF domain of ... [more]

Throughput

• Low Throughput

Additional Notes

• Sources of PPIL3 and SHARPIN not clear

Curated By

• BioGRID