KPNA2
Gene Ontology Biological Process
Gene Ontology Molecular Function
SGK1
Gene Ontology Biological Process
- ion transmembrane transport [TAS]
- long-term memory [TAS]
- positive regulation of transporter activity [TAS]
- regulation of apoptotic process [TAS]
- regulation of blood pressure [TAS]
- regulation of catalytic activity [TAS]
- regulation of cell growth [TAS]
- regulation of cell migration [TAS]
- regulation of cell proliferation [TAS]
- regulation of gastric acid secretion [TAS]
- regulation of sequence-specific DNA binding transcription factor activity [TAS]
- renal sodium ion absorption [TAS]
- response to stress [TAS]
- sodium ion transport [TAS]
- transmembrane transport [TAS]
Gene Ontology Molecular Function
Reconstituted Complex
An interaction is detected between purified proteins in vitro.
Publication
Importin-alpha mediates the regulated nuclear targeting of serum- and glucocorticoid-inducible protein kinase (Sgk) by recognition of a nuclear localization signal in the kinase central domain.
The transcriptionally regulated serum and glucocorticoid inducible protein kinase (Sgk) is localized to the nucleus in a serum-dependent manner, and a yeast two-hybrid genetic screen uncovered a specific interaction between Sgk and the importin-alpha nuclear import receptor. In vitro GST pull down assays demonstrated a strong and direct association of importin-alpha with endogenous Sgk and exogenously expressed HA-tagged Sgk, whereas ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| SGK1 KPNA2 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - | |
| SGK1 KPNA2 | Two-hybrid Two-hybrid Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation. | Low | - | BioGRID | - |
Curated By
- BioGRID