PDE6G
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
DNM2
Gene Ontology Biological Process
- G2/M transition of mitotic cell cycle [NAS]
- GTP catabolic process [NAS, TAS]
- antigen processing and presentation of exogenous peptide antigen via MHC class II [TAS]
- endocytosis [NAS]
- membrane organization [TAS]
- negative regulation of membrane tubulation [IDA]
- neuron projection morphogenesis [ISS]
- nitric oxide metabolic process [TAS]
- positive regulation of apoptotic process [NAS]
- positive regulation of transcription, DNA-templated [NAS]
- post-Golgi vesicle-mediated transport [TAS]
- receptor internalization [IMP]
- receptor-mediated endocytosis [ISS]
- regulation of axon extension [ISS]
- regulation of nitric-oxide synthase activity [TAS]
- regulation of transcription, DNA-templated [NAS]
- signal transduction [NAS]
- small molecule metabolic process [TAS]
- synaptic vesicle transport [NAS]
- transferrin transport [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Reconstituted Complex
An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator.
Publication
The inhibitory gamma subunit of the type 6 retinal cGMP phosphodiesterase functions to link c-Src and G-protein-coupled receptor kinase 2 in a signaling unit that regulates p42/p44 mitogen-activated protein kinase by epidermal growth factor.
The inhibitory gamma subunit of the retinal photoreceptor type 6 cGMP phosphodiesterase (PDEgamma) is phosphorylated by G-protein-coupled receptor kinase 2 on threonine 62 and regulates the epidermal growth factor- dependent stimulation of p42/p44 mitogen-activated protein kinase in human embryonic kidney 293 cells. We report here that PDEgamma is in a pre-formed complex with c-Src and that stimulation of cells with ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID