BAIT
RAD51
BRCC5, HRAD51, HsRad51, HsT16930, MRMV2, RAD51A, RECA
RAD51 recombinase
GO Process (16)
GO Function (8)
GO Component (10)
Gene Ontology Biological Process
- ATP catabolic process [IDA]
- DNA recombinase assembly [TAS]
- DNA recombination [TAS]
- DNA repair [TAS]
- DNA unwinding involved in DNA replication [IDA]
- cellular response to DNA damage stimulus [IDA]
- cellular response to camptothecin [IDA]
- cellular response to ionizing radiation [IDA]
- double-strand break repair [TAS]
- double-strand break repair via homologous recombination [IDA, IMP, TAS]
- meiotic nuclear division [ISS]
- mitotic recombination [TAS]
- positive regulation of DNA ligation [IDA]
- protein homooligomerization [IPI]
- reciprocal meiotic recombination [TAS]
- regulation of double-strand break repair via homologous recombination [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
NBN
AT-V1, AT-V2, ATV, NBS, NBS1, P95
nibrin
GO Process (13)
GO Function (5)
GO Component (8)
Gene Ontology Biological Process
- DNA damage checkpoint [IDA]
- DNA damage response, signal transduction by p53 class mediator [TAS]
- DNA duplex unwinding [IMP]
- DNA repair [TAS]
- cell cycle arrest [TAS]
- double-strand break repair [IDA, TAS]
- double-strand break repair via homologous recombination [TAS]
- mitotic G2 DNA damage checkpoint [IDA]
- mitotic cell cycle checkpoint [IDA]
- positive regulation of kinase activity [IDA]
- positive regulation of protein autophosphorylation [IDA]
- regulation of DNA-dependent DNA replication initiation [TAS]
- telomere maintenance [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Far Western
An interaction is detected between a protein immobilized on a membrane and a purified protein probe.
Publication
Plk1 and CK2 act in concert to regulate Rad51 during DNA double strand break repair.
Homologous recombination (HR) plays an important role in the maintenance of genome integrity. HR repairs broken DNA during S and G2 phases of the cell cycle but its regulatory mechanisms remain elusive. Here, we report that Polo-like kinase 1 (Plk1), which is vital for cell proliferation and is frequently upregulated in cancer cells, phosphorylates the essential Rad51 recombinase at serine ... [more]
Mol. Cell Feb. 10, 2012; 45(3);371-83 [Pubmed: 22325354]
Throughput
- Low Throughput
Curated By
- BioGRID