BAIT
PKP4
p0071
plakophilin 4
GO Process (5)
GO Function (1)
GO Component (12)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
CDH2
CD325, CDHN, CDw325, NCAD
cadherin 2, type 1, N-cadherin (neuronal)
GO Process (9)
GO Function (4)
GO Component (7)
Gene Ontology Biological Process
- adherens junction organization [TAS]
- cell adhesion [TAS]
- cell junction assembly [TAS]
- cell-cell adhesion mediated by cadherin [ISS]
- cell-cell junction organization [TAS]
- glial cell differentiation [ISS]
- muscle cell differentiation [TAS]
- neuronal stem cell maintenance [ISS]
- positive regulation of muscle cell differentiation [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
Targeting of p0071 to desmosomes and adherens junctions is mediated by different protein domains.
p0071, a member of the armadillo protein family, is most closely related to p120(ctn) and the plakophilins 1-3. Whereas plakophilins are desmosomal plaque proteins, p120(ctn) localizes to adherens junctions and interacts with classical cadherins. In contrast, p0071 has been described as a protein with dual localization in adherens junctions and desmosomes depending on the cell type examined. Here we have ... [more]
J. Cell. Sci. Apr. 01, 2003; 116(0);1219-33 [Pubmed: 12615965]
Throughput
- Low Throughput
Curated By
- BioGRID