NOX1
Gene Ontology Biological Process
- NADP metabolic process [IC]
- angiogenesis [IMP]
- cell migration [IMP]
- cellular stress response to acidic pH [IDA]
- hydrogen peroxide metabolic process [IDA]
- inflammatory response [TAS]
- intracellular pH elevation [IDA]
- oxidation-reduction process [IDA]
- positive regulation of cell proliferation [IDA]
- positive regulation of integrin biosynthetic process [IMP]
- positive regulation of smooth muscle cell proliferation [ISS]
- positive regulation vascular endothelial growth factor production [IEP]
- proton transport [IDA]
- regulation of blood pressure [TAS]
- respiratory burst [TAS]
- signal transduction [TAS]
- superoxide anion generation [IDA]
- superoxide metabolic process [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
NOXO1
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Reconstituted Complex
An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator.
Publication
Molecular interaction of NADPH oxidase 1 with betaPix and Nox Organizer 1.
It is well established that growth-factor-induced reactive oxygen species (ROS) act as second messengers in cell signaling. We have previously reported that betaPix, a guanine nucleotide exchange factor for Rac, interacts with NADPH oxidase 1 (Nox1) leading to EGF-induced ROS generation. Here, we report the identification of the domains of Nox1 and betaPix responsible for the interaction between the two ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID