An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.

Publication

Stasimon/Tmem41b localizes to mitochondria-associated ER membranes and is essential for mouse embryonic development.

Van Alstyne M, Lotti F, Dal Mas A, Area-Gomez E, Pellizzoni L

Stasimon (also known as Tmem41b) is an evolutionarily conserved transmembrane protein first identified for its contribution to motor system dysfunction in animal models of the childhood neurodegenerative disease spinal muscular atrophy (SMA). Stasimon was shown to be required for normal neurotransmission in the motor circuit of Drosophila larvae and proper development of motor axons in zebrafish embryos as well as ... [more]

Biochem. Biophys. Res. Commun. Dec. 30, 2017; 506(3);463-470 [Pubmed: 30352685]

Throughput

High Throughput

Curated By

BioGRID

Interaction Summary

TMEM41B

LRPPRC

Gene Ontology Biological Process

Gene Ontology Molecular Function

RNA binding [NAS]actin filament binding [IDA]beta-tubulin binding [IDA]microtubule binding [TAS]poly(A) RNA binding [IDA]protein binding [IPI]

Gene Ontology Cellular Component

Affinity Capture-MS

Publication

Stasimon/Tmem41b localizes to mitochondria-associated ER membranes and is essential for mouse embryonic development.

Throughput

Curated By

RNA binding [NAS]
actin filament binding [IDA]
beta-tubulin binding [IDA]
microtubule binding [TAS]
poly(A) RNA binding [IDA]
protein binding [IPI]