BAIT

RNF112

ZNF179, Zfp179, bfp, RP23-155J3.1
ring finger protein 112
GO Process (3)
GO Function (0)
GO Component (2)
Mus musculus
PREY

RNF112

ZNF179, Zfp179, bfp, RP23-155J3.1
ring finger protein 112
GO Process (3)
GO Function (0)
GO Component (2)
Mus musculus

Biochemical Activity (Ubiquitination)

An interaction is inferred from the biochemical effect of one protein upon another, for example, GTP-GDP exchange activity or phosphorylation of a substrate by a kinase. The bait protein executes the activity on the substrate hit protein. A Modification value is recorded for interactions of this type with the possible values Phosphorylation, Ubiquitination, Sumoylation, Dephosphorylation, Methylation, Prenylation, Acetylation, Deubiquitination, Proteolytic Processing, Glucosylation, Nedd(Rub1)ylation, Deacetylation, No Modification, Demethylation.

Publication

Znf179 E3 ligase-mediated TDP-43 polyubiquitination is involved in TDP-43- ubiquitinated inclusions (UBI) (+)-related neurodegenerative pathology.

Lee YC, Huang WC, Lin JH, Kao TJ, Lin HC, Lee KH, Lin HC, Shen CJ, Chang WC, Huang CC

The brain predominantly expressed RING finger protein, Znf179, is known to be important for embryonic neuronal differentiation during brain development. Downregulation of Znf179 has been observed in motor neurons of adult mouse models for amyotrophic lateral sclerosis (ALS), yet the molecular function of Znf179 in neurodegeneration has never been previously described. Znf179 contains the classical C3HC4 RING finger domain, and ... [more]

J. Biomed. Sci. Nov. 08, 2018; 25(1);76 [Pubmed: 30404641]

Throughput

  • Low Throughput

Additional Notes

  • E2: UbcH5a/UBE2D1, UbcH5b/UBE2D2, UbcH5c/UBE2D3, or UbcH6/UBE2E1

Curated By

  • BioGRID