BAIT

TANK

I-TRAF, ITRAF, TRAF2
TRAF family member-associated NFKB activator
GO Process (2)
GO Function (2)
GO Component (2)

Gene Ontology Biological Process

Gene Ontology Molecular Function

Gene Ontology Cellular Component

Homo sapiens
PREY

SNAP47

C1orf142, HEL170, SNAP-47, SVAP1, RP5-870F10.2
synaptosomal-associated protein, 47kDa
GO Process (2)
GO Function (3)
GO Component (3)

Gene Ontology Biological Process

Gene Ontology Molecular Function

Gene Ontology Cellular Component

Homo sapiens

Affinity Capture-MS

An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.

Publication

A protein-protein interaction map of the TNF-induced NF-κB signal transduction pathway.

Van Quickelberghe E, De Sutter D, van Loo G, Eyckerman S, Gevaert K

Tumor Necrosis Factor (TNF) has a crucial role in inflammation, cell proliferation and cell death. Dysregulation of TNF receptor 1 (TNFR1)-induced Nuclear Factor-kappa B (NF-κB) signaling leads to chronic inflammation and is associated with several human inflammatory pathologies. Hence, TNF neutralization suppresses inflammation and attenuates inflammatory pathology. However, despite its beneficial effects, anti-TNF therapy suffers from efficacy issues and severe ... [more]

Sci Data Dec. 18, 2017; 5();180289 [Pubmed: 30561431]

Throughput

  • High Throughput

Additional Notes

  • Virotrap

Curated By

  • BioGRID