BAIT
SHARPIN
SIPL1, PSEC0216
SHANK-associated RH domain interactor
GO Process (5)
GO Function (2)
GO Component (5)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
DHFR
DHFRP1, DYR
dihydrofolate reductase
GO Process (10)
GO Function (3)
GO Component (2)
Gene Ontology Biological Process
- G1/S transition of mitotic cell cycle [TAS]
- folic acid metabolic process [TAS]
- mitotic cell cycle [TAS]
- nitric oxide metabolic process [TAS]
- regulation of nitric-oxide synthase activity [TAS]
- regulation of transcription involved in G1/S transition of mitotic cell cycle [TAS]
- small molecule metabolic process [TAS]
- tetrahydrofolate metabolic process [IDA]
- vitamin metabolic process [TAS]
- water-soluble vitamin metabolic process [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- cytosol [TAS]
- nucleoplasm [TAS]
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
A protein-protein interaction map of the TNF-induced NF-κB signal transduction pathway.
Tumor Necrosis Factor (TNF) has a crucial role in inflammation, cell proliferation and cell death. Dysregulation of TNF receptor 1 (TNFR1)-induced Nuclear Factor-kappa B (NF-κB) signaling leads to chronic inflammation and is associated with several human inflammatory pathologies. Hence, TNF neutralization suppresses inflammation and attenuates inflammatory pathology. However, despite its beneficial effects, anti-TNF therapy suffers from efficacy issues and severe ... [more]
Sci Data Dec. 18, 2017; 5();180289 [Pubmed: 30561431]
Throughput
- High Throughput
Additional Notes
- Virotrap
Curated By
- BioGRID