BAIT

SHARPIN

SIPL1, PSEC0216
SHANK-associated RH domain interactor
UPS Project
Homo sapiens
PREY

LDOC1L

Mar6, Mart6, dJ1033E15.2
leucine zipper, down-regulated in cancer 1-like
GO Process (0)
GO Function (0)
GO Component (0)
Homo sapiens

Affinity Capture-MS

An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.

Publication

A protein-protein interaction map of the TNF-induced NF-κB signal transduction pathway.

Van Quickelberghe E, De Sutter D, van Loo G, Eyckerman S, Gevaert K

Tumor Necrosis Factor (TNF) has a crucial role in inflammation, cell proliferation and cell death. Dysregulation of TNF receptor 1 (TNFR1)-induced Nuclear Factor-kappa B (NF-κB) signaling leads to chronic inflammation and is associated with several human inflammatory pathologies. Hence, TNF neutralization suppresses inflammation and attenuates inflammatory pathology. However, despite its beneficial effects, anti-TNF therapy suffers from efficacy issues and severe ... [more]

Sci Data Dec. 18, 2017; 5();180289 [Pubmed: 30561431]

Throughput

  • High Throughput

Additional Notes

  • Virotrap

Curated By

  • BioGRID