BAIT
SHARPIN
SIPL1, PSEC0216
SHANK-associated RH domain interactor
GO Process (5)
GO Function (2)
GO Component (5)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
FZD7
FzE3
frizzled class receptor 7
GO Process (14)
GO Function (6)
GO Component (2)
Gene Ontology Biological Process
- canonical Wnt signaling pathway [IDA, IMP]
- cellular response to retinoic acid [ISS]
- mesenchymal to epithelial transition [IMP]
- negative regulation of cell-substrate adhesion [IMP]
- negative regulation of ectodermal cell fate specification [IMP]
- neuron differentiation [ISS]
- non-canonical Wnt signaling pathway via JNK cascade [IMP]
- positive regulation of JNK cascade [IC]
- positive regulation of epithelial cell proliferation involved in wound healing [IMP]
- positive regulation of phosphorylation [IDA]
- positive regulation of transcription, DNA-templated [IDA, IMP]
- regulation of catenin import into nucleus [IMP]
- regulation of transcription, DNA-templated [IMP]
- stem cell maintenance [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
A protein-protein interaction map of the TNF-induced NF-κB signal transduction pathway.
Tumor Necrosis Factor (TNF) has a crucial role in inflammation, cell proliferation and cell death. Dysregulation of TNF receptor 1 (TNFR1)-induced Nuclear Factor-kappa B (NF-κB) signaling leads to chronic inflammation and is associated with several human inflammatory pathologies. Hence, TNF neutralization suppresses inflammation and attenuates inflammatory pathology. However, despite its beneficial effects, anti-TNF therapy suffers from efficacy issues and severe ... [more]
Sci Data Dec. 18, 2017; 5();180289 [Pubmed: 30561431]
Throughput
- High Throughput
Additional Notes
- Virotrap
Curated By
- BioGRID