LIFR
Gene Ontology Biological Process
- cell surface receptor signaling pathway [TAS]
- ciliary neurotrophic factor-mediated signaling pathway [IDA]
- cytokine-mediated signaling pathway [IDA]
- leukemia inhibitory factor signaling pathway [IDA]
- oncostatin-M-mediated signaling pathway [IMP]
- positive regulation of cell proliferation [IDA]
- response to cytokine [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
LIF
Gene Ontology Biological Process
- leukemia inhibitory factor signaling pathway [IDA]
- multicellular organismal development [TAS]
- negative regulation of hormone secretion [IDA]
- positive regulation of MAPK cascade [IDA]
- positive regulation of cell proliferation [IDA]
- positive regulation of histone H3-K27 acetylation [IDA]
- positive regulation of macrophage differentiation [IDA]
- positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis [IDA]
- positive regulation of peptidyl-serine phosphorylation [IDA]
- positive regulation of peptidyl-serine phosphorylation of STAT protein [IDA]
- positive regulation of peptidyl-tyrosine phosphorylation [IDA]
- positive regulation of protein localization to nucleus [IDA]
- positive regulation of transcription from RNA polymerase II promoter [IDA]
- positive regulation of tyrosine phosphorylation of Stat1 protein [IDA]
- positive regulation of tyrosine phosphorylation of Stat3 protein [IDA]
- regulation of metanephric nephron tubule epithelial cell differentiation [IDA]
- transcription from RNA polymerase II promoter [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Reconstituted Complex
An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator.
Publication
Mutations in the immunoglobulin-like domain of gp190, the leukemia inhibitory factor (LIF) receptor, increase or decrease its affinity for LIF.
The leukemia inhibitory factor (LIF) receptor comprises the low affinity binding chain gp190 and the high affinity converter gp130. The ectodomain of gp190 is among the most complex in the hematopoietin receptor family, because it contains two typical cytokine receptor homology domains separated by an immunoglobulin-like (Ig-like) domain. Human and murine gp190 proteins share 76% homology, but murine gp190 binds ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID