BAIT
NRAS
ALPS4, CMNS, N-ras, NCMS, NRAS1, NS6, RP5-1000E10.2
neuroblastoma RAS viral (v-ras) oncogene homolog
GO Process (13)
GO Function (1)
GO Component (3)
Gene Ontology Biological Process
- Fc-epsilon receptor signaling pathway [TAS]
- MAPK cascade [TAS]
- Ras protein signal transduction [TAS]
- activation of MAPKK activity [TAS]
- axon guidance [TAS]
- blood coagulation [TAS]
- epidermal growth factor receptor signaling pathway [TAS]
- fibroblast growth factor receptor signaling pathway [TAS]
- innate immune response [TAS]
- insulin receptor signaling pathway [TAS]
- leukocyte migration [TAS]
- neurotrophin TRK receptor signaling pathway [TAS]
- small GTPase mediated signal transduction [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
HMOX1
HMOX1D, HO-1, HSP32, bK286B10, CTA-286B10.6
heme oxygenase (decycling) 1
GO Process (31)
GO Function (5)
GO Component (6)
Gene Ontology Biological Process
- angiogenesis [TAS]
- cell death [ISS]
- cellular iron ion homeostasis [TAS]
- cellular response to hypoxia [IEP]
- endothelial cell proliferation [TAS]
- erythrocyte homeostasis [IMP]
- excretion [IC]
- heme catabolic process [IDA, TAS]
- heme oxidation [IDA]
- intracellular signal transduction [TAS]
- iron ion homeostasis [IDA, IMP]
- low-density lipoprotein particle clearance [TAS]
- negative regulation of extrinsic apoptotic signaling pathway via death domain receptors [IMP]
- negative regulation of leukocyte migration [TAS]
- negative regulation of smooth muscle cell proliferation [IDA]
- porphyrin-containing compound metabolic process [TAS]
- positive regulation of I-kappaB kinase/NF-kappaB signaling [IMP]
- positive regulation of chemokine biosynthetic process [TAS]
- positive regulation of smooth muscle cell proliferation [IDA]
- positive regulation of vasodilation [IC]
- protein homooligomerization [IDA]
- regulation of angiogenesis [TAS]
- regulation of sequence-specific DNA binding transcription factor activity [ISS]
- regulation of transcription from RNA polymerase II promoter in response to oxidative stress [ISS]
- response to hydrogen peroxide [ISS]
- response to nicotine [IDA]
- response to oxidative stress [IMP]
- small molecule metabolic process [TAS]
- smooth muscle hyperplasia [TAS]
- transmembrane transport [TAS]
- wound healing involved in inflammatory response [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Proximity Label-MS
An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods.
Publication
Interrogating the protein interactomes of RAS isoforms identifies PIP5K1A as a KRAS-specific vulnerability.
In human cancers, oncogenic mutations commonly occur in the RAS genes KRAS, NRAS, or HRAS, but there are no clinical RAS inhibitors. Mutations are more prevalent in KRAS, possibly suggesting a unique oncogenic activity mediated by KRAS-specific interaction partners, which might be targeted. Here, we determine the specific protein interactomes of each RAS isoform by BirA proximity-dependent biotin identification. The ... [more]
Nat Commun Dec. 07, 2017; 9(1);3646 [Pubmed: 30194290]
Quantitative Score
- 4.84734777 [Confidence Score]
Throughput
- High Throughput
Additional Notes
- BioID system:Biotin-labled proteins with at least a 2-fold enrichment and p-value < 0.05 were considered significant.
Curated By
- BioGRID