KRAS
Gene Ontology Biological Process
- Fc-epsilon receptor signaling pathway [TAS]
- MAPK cascade [TAS]
- Ras protein signal transduction [TAS]
- activation of MAPKK activity [TAS]
- axon guidance [TAS]
- blood coagulation [TAS]
- epidermal growth factor receptor signaling pathway [TAS]
- fibroblast growth factor receptor signaling pathway [TAS]
- innate immune response [TAS]
- insulin receptor signaling pathway [TAS]
- leukocyte migration [TAS]
- neurotrophin TRK receptor signaling pathway [TAS]
- positive regulation of cell proliferation [IMP]
- positive regulation of gene expression [IMP]
- positive regulation of protein phosphorylation [IMP]
- small GTPase mediated signal transduction [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
NF1
Gene Ontology Biological Process
- MAPK cascade [ISS]
- Ras protein signal transduction [ISS]
- Schwann cell development [ISS]
- actin cytoskeleton organization [ISS]
- adrenal gland development [ISS]
- artery morphogenesis [ISS]
- brain development [ISS]
- camera-type eye morphogenesis [ISS]
- cell communication [ISS]
- cerebral cortex development [ISS]
- cognition [IMP]
- collagen fibril organization [ISS]
- extracellular matrix organization [ISS]
- forebrain astrocyte development [ISS]
- forebrain morphogenesis [ISS]
- heart development [ISS]
- liver development [ISS]
- metanephros development [ISS]
- myelination in peripheral nervous system [ISS]
- negative regulation of MAP kinase activity [ISS]
- negative regulation of MAPK cascade [IMP, ISS]
- negative regulation of Ras protein signal transduction [IBA]
- negative regulation of cell migration [IMP]
- negative regulation of endothelial cell proliferation [IMP]
- negative regulation of fibroblast proliferation [ISS]
- negative regulation of neuroblast proliferation [ISS]
- negative regulation of oligodendrocyte differentiation [ISS]
- negative regulation of protein kinase activity [ISS]
- negative regulation of transcription factor import into nucleus [ISS]
- osteoblast differentiation [ISS]
- peripheral nervous system development [ISS]
- phosphatidylinositol 3-kinase signaling [ISS]
- pigmentation [ISS]
- positive regulation of Ras GTPase activity [IDA, IMP, ISS]
- positive regulation of adenylate cyclase activity [ISS]
- positive regulation of apoptotic process [ISS]
- positive regulation of neuron apoptotic process [ISS]
- regulation of Ras GTPase activity [IMP]
- regulation of angiogenesis [IMP]
- regulation of blood vessel endothelial cell migration [IMP]
- regulation of bone resorption [ISS]
- regulation of cell-matrix adhesion [ISS]
- regulation of glial cell differentiation [ISS]
- response to hypoxia [ISS]
- smooth muscle tissue development [ISS]
- spinal cord development [ISS]
- sympathetic nervous system development [ISS]
- visual learning [ISS]
- wound healing [ISS]
Gene Ontology Molecular Function
Proximity Label-MS
An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods.
Publication
Interrogating the protein interactomes of RAS isoforms identifies PIP5K1A as a KRAS-specific vulnerability.
In human cancers, oncogenic mutations commonly occur in the RAS genes KRAS, NRAS, or HRAS, but there are no clinical RAS inhibitors. Mutations are more prevalent in KRAS, possibly suggesting a unique oncogenic activity mediated by KRAS-specific interaction partners, which might be targeted. Here, we determine the specific protein interactomes of each RAS isoform by BirA proximity-dependent biotin identification. The ... [more]
Quantitative Score
- 8.151217572 [Confidence Score]
Throughput
- High Throughput
Additional Notes
- BioID system:Biotin-labled proteins with at least a 2-fold enrichment and p-value < 0.05 were considered significant.
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| KRAS NF1 | Proximity Label-MS Proximity Label-MS An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods. | High | 72.92 | BioGRID | 2991485 | |
| KRAS NF1 | Proximity Label-MS Proximity Label-MS An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods. | High | - | BioGRID | 2548281 | |
| KRAS NF1 | Synthetic Lethality Synthetic Lethality A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition. | High | - | BioGRID | 1414651 |
Curated By
- BioGRID