KRAS
Gene Ontology Biological Process
- Fc-epsilon receptor signaling pathway [TAS]
- MAPK cascade [TAS]
- Ras protein signal transduction [TAS]
- activation of MAPKK activity [TAS]
- axon guidance [TAS]
- blood coagulation [TAS]
- epidermal growth factor receptor signaling pathway [TAS]
- fibroblast growth factor receptor signaling pathway [TAS]
- innate immune response [TAS]
- insulin receptor signaling pathway [TAS]
- leukocyte migration [TAS]
- neurotrophin TRK receptor signaling pathway [TAS]
- positive regulation of cell proliferation [IMP]
- positive regulation of gene expression [IMP]
- positive regulation of protein phosphorylation [IMP]
- small GTPase mediated signal transduction [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
SEMA4D
Gene Ontology Biological Process
- axon guidance [TAS]
- cell adhesion [TAS]
- immune response [TAS]
- leukocyte aggregation [IMP]
- negative regulation of alkaline phosphatase activity [IMP]
- negative regulation of apoptotic process [TAS]
- negative regulation of cell adhesion [IDA]
- negative regulation of osteoblast differentiation [ISS]
- negative regulation of peptidyl-tyrosine phosphorylation [ISS]
- negative regulation of transcription from RNA polymerase II promoter [IMP]
- ossification involved in bone maturation [IMP]
- positive regulation of Rho GTPase activity [IMP, ISS]
- positive regulation of cell migration [IDA, ISS]
- positive regulation of collateral sprouting [IMP]
- positive regulation of peptidyl-tyrosine phosphorylation [ISS]
- positive regulation of phosphatidylinositol 3-kinase signaling [IMP]
- positive regulation of protein phosphorylation [IDA]
- regulation of cell projection organization [IMP]
- regulation of cell shape [IMP]
- regulation of dendrite morphogenesis [IMP]
- semaphorin-plexin signaling pathway [IDA, IMP]
- semaphorin-plexin signaling pathway involved in bone trabecula morphogenesis [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Proximity Label-MS
An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods.
Publication
Interrogating the protein interactomes of RAS isoforms identifies PIP5K1A as a KRAS-specific vulnerability.
In human cancers, oncogenic mutations commonly occur in the RAS genes KRAS, NRAS, or HRAS, but there are no clinical RAS inhibitors. Mutations are more prevalent in KRAS, possibly suggesting a unique oncogenic activity mediated by KRAS-specific interaction partners, which might be targeted. Here, we determine the specific protein interactomes of each RAS isoform by BirA proximity-dependent biotin identification. The ... [more]
Quantitative Score
- 4.345156431 [Confidence Score]
Throughput
- High Throughput
Additional Notes
- BioID system:Biotin-labled proteins with at least a 2-fold enrichment and p-value < 0.05 were considered significant.
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| KRAS SEMA4D | Proximity Label-MS Proximity Label-MS An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods. | High | 60 | BioGRID | 2991800 |
Curated By
- BioGRID