BAIT
TFAP2A
AP-2, AP-2alpha, AP2TF, BOFS, TFAP2, RP1-290I10.1
transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
GO Process (28)
GO Function (15)
GO Component (6)
Gene Ontology Biological Process
- bone morphogenesis [ISS]
- cellular response to iron ion [IDA]
- embryonic cranial skeleton morphogenesis [ISS]
- embryonic forelimb morphogenesis [ISS]
- eyelid development in camera-type eye [ISS]
- inner ear morphogenesis [IMP]
- kidney development [IMP]
- negative regulation of apoptotic process [IDA]
- negative regulation of cell proliferation [IDA]
- negative regulation of reactive oxygen species metabolic process [IDA]
- negative regulation of transcription by competitive promoter binding [IDA, IMP]
- negative regulation of transcription from RNA polymerase II promoter [IDA]
- negative regulation of transcription, DNA-templated [IDA]
- oculomotor nerve formation [ISS]
- optic cup structural organization [ISS]
- optic vesicle morphogenesis [ISS]
- palate development [IMP]
- positive regulation of bone mineralization [IDA]
- positive regulation of gene expression [ISS]
- positive regulation of neuron apoptotic process [IDA]
- positive regulation of tooth mineralization [IDA]
- positive regulation of transcription from RNA polymerase II promoter [IDA]
- positive regulation of transcription, DNA-templated [IDA, ISS]
- regulation of cell differentiation [IDA]
- retina layer formation [IEP]
- sensory perception of sound [IMP]
- transcription from RNA polymerase II promoter [IDA]
- trigeminal nerve development [ISS]
Gene Ontology Molecular Function- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA]
- RNA polymerase II core promoter sequence-specific DNA binding [IDA]
- chromatin binding [ISS]
- core promoter proximal region sequence-specific DNA binding [IDA]
- protein binding [IPI]
- protein dimerization activity [IDA]
- protein homodimerization activity [TAS]
- sequence-specific DNA binding [IDA]
- sequence-specific DNA binding RNA polymerase II transcription factor activity [IDA]
- transcription coactivator activity [IDA]
- transcription regulatory region DNA binding [IDA]
- transcription regulatory region sequence-specific DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA]
- RNA polymerase II core promoter sequence-specific DNA binding [IDA]
- chromatin binding [ISS]
- core promoter proximal region sequence-specific DNA binding [IDA]
- protein binding [IPI]
- protein dimerization activity [IDA]
- protein homodimerization activity [TAS]
- sequence-specific DNA binding [IDA]
- sequence-specific DNA binding RNA polymerase II transcription factor activity [IDA]
- transcription coactivator activity [IDA]
- transcription regulatory region DNA binding [IDA]
- transcription regulatory region sequence-specific DNA binding [IDA]
Gene Ontology Cellular Component
Homo sapiens
PREY
CITED2
ASD8, MRG-1, MRG1, P35SRJ, VSD2
Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
GO Process (31)
GO Function (8)
GO Component (3)
Gene Ontology Biological Process
- adrenal cortex formation [ISS]
- cell proliferation [IDA]
- determination of left/right symmetry [ISS]
- embryonic heart tube left/right pattern formation [ISS]
- heart development [IMP, ISS]
- left/right axis specification [ISS]
- liver development [ISS]
- negative regulation of apoptotic process [ISS]
- negative regulation of cell migration [IMP]
- negative regulation of gene expression [IDA]
- negative regulation of transcription from RNA polymerase II promoter [IMP]
- negative regulation of transcription from RNA polymerase II promoter in response to hypoxia [IDA]
- negative regulation of transcription, DNA-templated [IDA, IMP]
- nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry [ISS]
- outflow tract morphogenesis [ISS]
- positive regulation of cell cycle [ISS]
- positive regulation of cell-cell adhesion [ISS]
- positive regulation of gene expression [IDA]
- positive regulation of male gonad development [ISS]
- positive regulation of peroxisome proliferator activated receptor signaling pathway [IDA]
- positive regulation of transcription from RNA polymerase II promoter [IDA, ISS]
- positive regulation of transcription, DNA-templated [IDA, ISS]
- positive regulation of transforming growth factor beta receptor signaling pathway [ISS]
- regulation of nucleic acid-templated transcription [IDA]
- regulation of organ formation [ISS]
- response to estrogen [IDA]
- response to fluid shear stress [IMP]
- response to hypoxia [IDA, IMP]
- sex determination [ISS]
- spleen development [ISS]
- ventricular septum morphogenesis [ISS]
Gene Ontology Molecular Function- LBD domain binding [IPI]
- RNA polymerase II transcription corepressor activity [IDA]
- chromatin binding [ISS]
- histone acetyltransferase binding [IDA]
- protein binding [IPI]
- sequence-specific DNA binding transcription factor activity [ISS]
- transcription coactivator activity [IDA]
- transcription corepressor activity [IDA, IMP]
- LBD domain binding [IPI]
- RNA polymerase II transcription corepressor activity [IDA]
- chromatin binding [ISS]
- histone acetyltransferase binding [IDA]
- protein binding [IPI]
- sequence-specific DNA binding transcription factor activity [ISS]
- transcription coactivator activity [IDA]
- transcription corepressor activity [IDA, IMP]
Homo sapiens
Far Western
An interaction is detected between a protein immobilized on a membrane and a purified protein probe.
Publication
Physical and functional interactions among AP-2 transcription factors, p300/CREB-binding protein, and CITED2.
The transcriptional co-activators and histone acetyltransferases p300/CREB-binding protein (CBP) interact with CITED2, a transcription factor AP-2 (TFAP2) co-activator. p300/CBP, CITED2, and TFAP2A are essential for normal neural tube and cardiac development. Here we show that p300 and CBP co-activate TFAP2A in the presence of CITED2. TFAP2A transcriptional activity was modestly impaired in p300(+/-) and CBP(+/-) mouse embryonic fibroblasts; this was ... [more]
J. Biol. Chem. May. 02, 2003; 278(18);16021-9 [Pubmed: 12586840]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| CITED2 TFAP2A | Reconstituted Complex Reconstituted Complex An interaction is detected between purified proteins in vitro. | Low | - | BioGRID | - | |
| CITED2 TFAP2A | Two-hybrid Two-hybrid Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation. | Low | - | BioGRID | - |
Curated By
- BioGRID