TNFRSF1A
Gene Ontology Biological Process
- cell surface receptor signaling pathway [IMP]
- cytokine-mediated signaling pathway [IMP]
- defense response [IMP]
- defense response to bacterium [IMP]
- inflammatory response [IMP]
- intrinsic apoptotic signaling pathway in response to DNA damage [IMP]
- negative regulation of apoptotic process [ISO]
- negative regulation of gene expression [ISO]
- negative regulation of inflammatory response [ISO]
- negative regulation of interleukin-6 production [ISO]
- positive regulation of angiogenesis [ISO]
- positive regulation of gene expression [ISO]
- positive regulation of inflammatory response [IMP]
- positive regulation of neuron apoptotic process [ISO]
- positive regulation of protein import into nucleus, translocation [ISO]
- positive regulation of transcription from RNA polymerase II promoter [IMP, ISO]
- positive regulation of tumor necrosis factor production [ISO]
- positive regulation of tyrosine phosphorylation of Stat1 protein [ISO]
- programmed cell death [IPI]
- prostaglandin metabolic process [TAS]
- protein heterooligomerization [ISO]
- regulation of apoptotic process [ISO]
- tumor necrosis factor-mediated signaling pathway [IMP, ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
CYBA
Gene Ontology Biological Process
- cellular response to organic substance [ISO]
- cytochrome complex assembly [ISO]
- hydrogen peroxide biosynthetic process [ISO]
- inflammatory response [ISO]
- innate immune response [ISO]
- negative regulation of glomerular filtration by angiotensin [ISO]
- oxidation-reduction process [ISO]
- positive regulation of cell growth [ISO]
- positive regulation of endothelial cell proliferation [ISO]
- positive regulation of mucus secretion [IMP]
- positive regulation of smooth muscle cell proliferation [ISO]
- positive regulation of superoxide anion generation [ISO]
- reactive oxygen species metabolic process [IMP]
- regulation of blood pressure [ISO]
- regulation of release of sequestered calcium ion into cytosol [IMP]
- respiratory burst [ISO]
- smooth muscle hypertrophy [ISO]
- superoxide anion generation [ISO]
- superoxide metabolic process [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Riboflavin kinase couples TNF receptor 1 to NADPH oxidase.
Reactive oxygen species (ROS) produced by NADPH oxidase function as defence and signalling molecules related to innate immunity and various cellular responses. The activation of NADPH oxidase in response to plasma membrane receptor activation depends on the phosphorylation of cytoplasmic oxidase subunits, their translocation to membranes and the assembly of all NADPH oxidase components. Tumour necrosis factor (TNF) is a ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID