BAIT
DISC1
C1orf136, SCZD9, RP4-730B13.1
disrupted in schizophrenia 1
GO Process (4)
GO Function (1)
GO Component (2)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
LRP4
CLSS, LRP-4, LRP10, MEGF7, SOST2
low density lipoprotein receptor-related protein 4
GO Process (14)
GO Function (3)
GO Component (7)
Gene Ontology Biological Process
- dendrite morphogenesis [ISS]
- extracellular matrix organization [TAS]
- kidney development [IDA]
- limb development [IDA]
- negative regulation of axonogenesis [ISS]
- negative regulation of canonical Wnt signaling pathway [IDA, IMP]
- negative regulation of ossification [IMP]
- positive regulation of presynaptic membrane organization [ISS]
- postsynaptic membrane assembly [ISS]
- presynaptic membrane assembly [ISS]
- protein heterotetramerization [ISS]
- skeletal muscle acetylcholine-gated channel clustering [ISS]
- synapse organization [ISS]
- synaptic growth at neuromuscular junction [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Endogenous Cell Type-Specific Disrupted in Schizophrenia 1 Interactomes Reveal Protein Networks Associated With Neurodevelopmental Disorders.
Disrupted in schizophrenia 1 (DISC1) has been implicated in a number of psychiatric diseases along with neurodevelopmental phenotypes such as the proliferation and differentiation of neural progenitor cells. While there has been significant effort directed toward understanding the function of DISC1 through the determination of its protein-protein interactions within an in vitro setting, endogenous interactions involving DISC1 within a cell type-specific ... [more]
Biol. Psychiatry Dec. 15, 2018; 85(4);305-316 [Pubmed: 29961565]
Throughput
- High Throughput
Additional Notes
- Human neural progenitor cells (hNPCs)
Curated By
- BioGRID