BAIT
DISC1
C1orf136, SCZD9, RP4-730B13.1
disrupted in schizophrenia 1
GO Process (4)
GO Function (1)
GO Component (2)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
SEMA3A
COLL1, HH16, Hsema-I, Hsema-III, SEMA1, SEMAD, SEMAIII, SEMAL, SemD, coll-1
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A
GO Process (15)
GO Function (2)
GO Component (1)
Gene Ontology Biological Process
- axon extension involved in axon guidance [ISS]
- axon guidance [TAS]
- axonogenesis involved in innervation [ISS]
- nerve development [ISS]
- neural crest cell migration involved in autonomic nervous system development [ISS]
- neuron migration [ISS]
- olfactory bulb development [IMP]
- regulation of axon extension involved in axon guidance [IDA]
- semaphorin-plexin signaling pathway [TAS]
- semaphorin-plexin signaling pathway involved in neuron projection guidance [ISS]
- sensory system development [TAS]
- sympathetic ganglion development [ISS]
- sympathetic nervous system development [TAS]
- sympathetic neuron projection extension [ISS]
- sympathetic neuron projection guidance [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Endogenous Cell Type-Specific Disrupted in Schizophrenia 1 Interactomes Reveal Protein Networks Associated With Neurodevelopmental Disorders.
Disrupted in schizophrenia 1 (DISC1) has been implicated in a number of psychiatric diseases along with neurodevelopmental phenotypes such as the proliferation and differentiation of neural progenitor cells. While there has been significant effort directed toward understanding the function of DISC1 through the determination of its protein-protein interactions within an in vitro setting, endogenous interactions involving DISC1 within a cell type-specific ... [more]
Biol. Psychiatry Dec. 15, 2018; 85(4);305-316 [Pubmed: 29961565]
Throughput
- High Throughput
Additional Notes
- Human neural progenitor cells (hNPCs)
Curated By
- BioGRID