TGM2
Gene Ontology Biological Process
- G-protein coupled receptor signaling pathway [TAS]
- apoptotic cell clearance [ISO]
- blood vessel remodeling [ISO]
- branching involved in salivary gland morphogenesis [IMP]
- isopeptide cross-linking via N6-(L-isoglutamyl)-L-lysine [ISO]
- negative regulation of endoplasmic reticulum calcium ion concentration [IMP, ISO]
- peptide cross-linking [TAS]
- phospholipase C-activating G-protein coupled receptor signaling pathway [ISA]
- positive regulation of I-kappaB kinase/NF-kappaB signaling [ISO]
- positive regulation of apoptotic process [ISO]
- positive regulation of cell adhesion [IMP]
- positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway [ISO]
- positive regulation of inflammatory response [ISO]
- positive regulation of mitochondrial calcium ion concentration [IMP, ISO]
- positive regulation of smooth muscle cell proliferation [ISO]
- protein homooligomerization [ISO]
- salivary gland cavitation [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
HSPA9
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Transglutaminase Type 2 Regulates ER-Mitochondria Contact Sites by Interacting with GRP75.
Transglutaminase type 2 (TG2) is a multifunctional enzyme that plays a key role in mitochondria homeostasis under stressful cellular conditions. TG2 interactome analysis reveals an enzyme interaction with GRP75 (glucose-regulated protein 75). GRP75 localizes in mitochondria-associated membranes (MAMs) and acts as a bridging molecule between the two organelles by assembling the IP3R-GRP75-VDAC complex, which is involved in the transport of ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID