VDAC1
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
ITPR3
Gene Ontology Biological Process
- G-protein coupled receptor signaling pathway [ISO]
- calcium ion transmembrane transport [ISO]
- calcium ion transport [IDA]
- calcium ion transport into cytosol [IDA]
- cellular response to cAMP [ISO]
- inositol phosphate-mediated signaling [IDA, ISO]
- long-term synaptic potentiation [IMP]
- memory [IMP]
- positive regulation of cytosolic calcium ion concentration [ISO]
- protein heterooligomerization [ISO]
- protein homooligomerization [ISO]
- response to calcium ion [ISO]
- sensory perception of bitter taste [IMP]
- sensory perception of sweet taste [IMP]
- sensory perception of umami taste [IMP]
Gene Ontology Molecular Function- calcium ion binding [ISO]
- inositol 1,3,4,5 tetrakisphosphate binding [ISO]
- inositol 1,4,5 trisphosphate binding [ISO]
- inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity [IDA, ISO]
- inositol hexakisphosphate binding [ISO]
- intracellular ligand-gated calcium channel activity [IDA]
- phosphatidylinositol binding [IDA]
- protein binding [IPI]
- calcium ion binding [ISO]
- inositol 1,3,4,5 tetrakisphosphate binding [ISO]
- inositol 1,4,5 trisphosphate binding [ISO]
- inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity [IDA, ISO]
- inositol hexakisphosphate binding [ISO]
- intracellular ligand-gated calcium channel activity [IDA]
- phosphatidylinositol binding [IDA]
- protein binding [IPI]
Gene Ontology Cellular Component
- apical part of cell [ISO]
- brush border [ISO]
- cytoplasm [IDA, ISO]
- cytosol [ISO]
- dendrite [ISO]
- endoplasmic reticulum [ISO]
- endoplasmic reticulum membrane [IDA, ISO]
- integral component of plasma membrane [ISO]
- membrane [ISO]
- myelin sheath [ISO]
- neuronal cell body [ISO]
- nuclear envelope [ISO]
- nuclear outer membrane [ISO]
- nucleolus [IDA]
- nucleoplasm [IDA]
- nucleus [IDA]
- perinuclear region of cytoplasm [ISO]
- plasma membrane [ISO]
- receptor complex [ISO]
Co-localization
Interaction inferred from two proteins that co-localize in the cell by indirect immunofluorescence only when in addition, if one gene is deleted, the other protein becomes mis-localized. Also includes co-dependent association of proteins with promoter DNA in chromatin immunoprecipitation experiments.
Publication
Transglutaminase Type 2 Regulates ER-Mitochondria Contact Sites by Interacting with GRP75.
Transglutaminase type 2 (TG2) is a multifunctional enzyme that plays a key role in mitochondria homeostasis under stressful cellular conditions. TG2 interactome analysis reveals an enzyme interaction with GRP75 (glucose-regulated protein 75). GRP75 localizes in mitochondria-associated membranes (MAMs) and acts as a bridging molecule between the two organelles by assembling the IP3R-GRP75-VDAC complex, which is involved in the transport of ... [more]
Throughput
- Low Throughput
Additional Notes
- Proximity Ligation Assay
Curated By
- BioGRID