Reconstituted Complex

An interaction is detected between purified proteins in vitro.

Publication

Fission yeast myosin Myo2 is down-regulated in actin affinity by light chain phosphorylation.

Pollard LW, Bookwalter CS, Tang Q, Krementsova EB, Trybus KM, Lowey S

Studies in fission yeast Schizosaccharomyces pombe have provided the basis for the most advanced models of the dynamics of the cytokinetic contractile ring. Myo2, a class-II myosin, is the major source of tension in the contractile ring, but how Myo2 is anchored and regulated to produce force is poorly understood. To enable more detailed biochemical/biophysical studies, Myo2 was expressed in ... [more]

Proc. Natl. Acad. Sci. U.S.A. Dec. 29, 2016; 114(35);E7236-E7244 [Pubmed: 28808035]

Throughput

  • Low Throughput

Related interactions

InteractionExperimental Evidence CodeDatasetThroughputScoreCurated ByNotes
ACT1 MYO2
Synthetic Growth Defect
Synthetic Growth Defect

A genetic interaction is inferred when mutations in separate genes, each of which alone causes a minimal phenotype, result in a significant growth defect under a given condition when combined in the same cell.

Low-BioGRID
863621
ACT1 MYO2
Synthetic Lethality
Synthetic Lethality

A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.

Low-BioGRID
863617

Curated By

  • BioGRID