CCR4
Gene Ontology Biological Process
Gene Ontology Molecular Function
CLR4
Gene Ontology Biological Process
- attachment of mitotic spindle microtubules to kinetochore [IMP]
- cellular protein localization [IMP]
- chromatin silencing at centromere [IMP]
- chromatin silencing at rDNA [IMP]
- chromatin silencing at silent mating-type cassette [IMP]
- chromatin silencing at telomere [TAS]
- chromatin silencing by small RNA [IMP]
- donor selection [IMP]
- heterochromatin assembly [NAS]
- heterochromatin maintenance involved in chromatin silencing at centromere outer repeat region [IGI]
- histone H3-K9 methylation [IDA]
- meiotic telomere clustering [IMP]
- negative regulation of transcription from RNA polymerase II promoter [IMP]
- peptidyl-lysine methylation [IDA]
- regulation of Ran protein signal transduction [TAS]
- regulation of production of siRNA involved in RNA interference [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Synthetic Lethality
A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.
Publication
Iron homeostasis regulates facultative heterochromatin assembly in adaptive genome control.
Iron metabolism is critical for sustaining life and maintaining human health. Here, we find that iron homeostasis is linked to facultative heterochromatin assembly and regulation of gene expression during adaptive genome control. We show that the fission yeast Clr4/Suv39h histone methyltransferase is part of a rheostat-like mechanism in which transcriptional upregulation of mRNAs in response to environmental change provides feedback ... [more]
Throughput
- Low Throughput
Ontology Terms
- phenotype: vegetative growth (APO:0000106)
- phenotype: cold sensitivity (APO:0000148)
Additional Notes
- deletion of clr4 is lethal in a ccr4/fep1 double mutant background
- genetic complex
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| CLR4 CCR4 | Negative Genetic Negative Genetic Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores. | High | -8.8878 | BioGRID | 527210 |
Curated By
- BioGRID