BAIT
USP14
TGT
ubiquitin specific peptidase 14 (tRNA-guanine transglycosylase)
GO Process (6)
GO Function (7)
GO Component (5)
Gene Ontology Biological Process
- negative regulation of ER-associated ubiquitin-dependent protein catabolic process [IMP]
- negative regulation of endopeptidase activity [IMP]
- proteasome-mediated ubiquitin-dependent protein catabolic process [IBA]
- protein deubiquitination [IDA]
- regulation of chemotaxis [IMP]
- regulation of proteasomal protein catabolic process [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
EXOSC10
PM-Scl, PM/Scl-100, PMSCL, PMSCL2, RRP6, Rrp6p, p2, p3, p4
exosome component 10
GO Process (9)
GO Function (3)
GO Component (7)
Gene Ontology Biological Process
- CUT catabolic process [IMP]
- RNA phosphodiester bond hydrolysis, exonucleolytic [IDA]
- histone mRNA catabolic process [IMP]
- maturation of 5.8S rRNA [IMP]
- nuclear mRNA surveillance [IMP]
- nuclear polyadenylation-dependent rRNA catabolic process [IMP]
- nuclear retention of unspliced pre-mRNA at the site of transcription [IMP]
- nuclear-transcribed mRNA catabolic process [IMP]
- nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Proteome-wide analysis of USP14 substrates revealed its role in hepatosteatosis via stabilization of FASN.
Ubiquitin-specific protease 14 (USP14) is one of the major proteasome-associated deubiquitinating enzymes critical for proteome homeostasis. However, substrates of USP14 remain largely unknown, hindering the understanding of its functional roles. Here we conduct a comprehensive proteome, ubiquitinome and interactome analysis for USP14 substrate screening. Bioinformatics analysis reveals broad new potential roles of USP14, especially in lipid and carbohydrate metabolism. Among ... [more]
Nat Commun Dec. 13, 2017; 9(1);4770 [Pubmed: 30425250]
Throughput
- High Throughput
Curated By
- BioGRID