BAIT
USP14
TGT
ubiquitin specific peptidase 14 (tRNA-guanine transglycosylase)
GO Process (6)
GO Function (7)
GO Component (5)
Gene Ontology Biological Process
- negative regulation of ER-associated ubiquitin-dependent protein catabolic process [IMP]
- negative regulation of endopeptidase activity [IMP]
- proteasome-mediated ubiquitin-dependent protein catabolic process [IBA]
- protein deubiquitination [IDA]
- regulation of chemotaxis [IMP]
- regulation of proteasomal protein catabolic process [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
CHP1
CHP, SLC9A1BP, Sid470p, p22, p24
calcineurin-like EF-hand protein 1
GO Process (24)
GO Function (7)
GO Component (9)
Gene Ontology Biological Process
- cellular response to acidic pH [ISS]
- cytoplasmic microtubule organization [ISS]
- membrane docking [ISS]
- membrane fusion [ISS]
- membrane organization [ISS]
- microtubule bundle formation [ISS]
- negative regulation of NF-kappaB transcription factor activity [IDA]
- negative regulation of calcineurin-NFAT signaling cascade [IDA]
- negative regulation of phosphatase activity [IDA]
- negative regulation of protein autophosphorylation [ISS]
- negative regulation of protein import into nucleus [IDA]
- negative regulation of protein kinase activity [ISS]
- negative regulation of protein phosphorylation [ISS]
- negative regulation of protein ubiquitination [ISS]
- positive regulation of protein glycosylation [ISS]
- positive regulation of protein targeting to membrane [ISS]
- positive regulation of protein transport [ISS]
- positive regulation of sodium:proton antiporter activity [IDA, ISS]
- potassium ion transport [TAS]
- protein export from nucleus [ISS]
- protein stabilization [ISS]
- regulation of intracellular pH [IDA]
- regulation of neuron death [IMP]
- small GTPase mediated signal transduction [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Proteome-wide analysis of USP14 substrates revealed its role in hepatosteatosis via stabilization of FASN.
Ubiquitin-specific protease 14 (USP14) is one of the major proteasome-associated deubiquitinating enzymes critical for proteome homeostasis. However, substrates of USP14 remain largely unknown, hindering the understanding of its functional roles. Here we conduct a comprehensive proteome, ubiquitinome and interactome analysis for USP14 substrate screening. Bioinformatics analysis reveals broad new potential roles of USP14, especially in lipid and carbohydrate metabolism. Among ... [more]
Nat Commun Dec. 13, 2017; 9(1);4770 [Pubmed: 30425250]
Throughput
- High Throughput
Curated By
- BioGRID