BAIT
NR2C2
TAK1, TR4
nuclear receptor subfamily 2, group C, member 2
GO Process (5)
GO Function (6)
GO Component (1)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- nucleoplasm [IDA, TAS]
Homo sapiens
PREY
AP2M1
AP50, CLAPM1, mu2
adaptor-related protein complex 2, mu 1 subunit
GO Process (11)
GO Function (5)
GO Component (7)
Gene Ontology Biological Process
- antigen processing and presentation of exogenous peptide antigen via MHC class II [TAS]
- axon guidance [TAS]
- clathrin-mediated endocytosis [TAS]
- epidermal growth factor receptor signaling pathway [TAS]
- membrane organization [TAS]
- negative regulation of epidermal growth factor receptor signaling pathway [TAS]
- negative regulation of protein localization to plasma membrane [IMP]
- neurotrophin TRK receptor signaling pathway [TAS]
- regulation of defense response to virus by virus [TAS]
- synaptic transmission [TAS]
- viral process [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
BAP1 regulation of the key adaptor protein NCoR1 is critical for γ-globin gene repression.
Human globin gene production transcriptionally "switches" from fetal to adult synthesis shortly after birth and is controlled by macromolecular complexes that enhance or suppress transcription by cis elements scattered throughout the locus. The DRED (direct repeat erythroid-definitive) repressor is recruited to the ε-globin and γ-globin promoters by the orphan nuclear receptors TR2 (NR2C1) and TR4 (NR2C2) to engender their silencing ... [more]
Genes Dev. Dec. 01, 2017; 32(23-24);1537-1549 [Pubmed: 30463901]
Throughput
- High Throughput
Additional Notes
- assayed using BioID (proximity-dependent biotin identification)
Curated By
- BioGRID