BAIT
NR2C2
TAK1, TR4
nuclear receptor subfamily 2, group C, member 2
GO Process (5)
GO Function (6)
GO Component (1)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- nucleoplasm [IDA, TAS]
Homo sapiens
PREY
AGRN
CMSPPD, RP11-54O7.13-009
agrin
GO Process (19)
GO Function (8)
GO Component (9)
Gene Ontology Biological Process
- G-protein coupled acetylcholine receptor signaling pathway [TAS]
- axon guidance [TAS]
- carbohydrate metabolic process [TAS]
- chondroitin sulfate metabolic process [TAS]
- clustering of voltage-gated sodium channels [TAS]
- extracellular matrix organization [TAS]
- glycosaminoglycan biosynthetic process [TAS]
- glycosaminoglycan catabolic process [TAS]
- glycosaminoglycan metabolic process [TAS]
- phototransduction, visible light [TAS]
- positive regulation of Rho GTPase activity [ISS]
- positive regulation of filopodium assembly [ISS]
- positive regulation of synaptic growth at neuromuscular junction [ISS]
- positive regulation of transcription from RNA polymerase II promoter [ISS]
- receptor clustering [IDA, IMP]
- retinoid metabolic process [TAS]
- signal transduction [TAS]
- small molecule metabolic process [TAS]
- synapse organization [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
BAP1 regulation of the key adaptor protein NCoR1 is critical for γ-globin gene repression.
Human globin gene production transcriptionally "switches" from fetal to adult synthesis shortly after birth and is controlled by macromolecular complexes that enhance or suppress transcription by cis elements scattered throughout the locus. The DRED (direct repeat erythroid-definitive) repressor is recruited to the ε-globin and γ-globin promoters by the orphan nuclear receptors TR2 (NR2C1) and TR4 (NR2C2) to engender their silencing ... [more]
Genes Dev. Dec. 01, 2017; 32(23-24);1537-1549 [Pubmed: 30463901]
Throughput
- High Throughput
Additional Notes
- assayed using BioID (proximity-dependent biotin identification)
Curated By
- BioGRID