BAIT
PPP1CC
PP-1G, PP1C, PPP1G
protein phosphatase 1, catalytic subunit, gamma isozyme
GO Process (9)
GO Function (6)
GO Component (9)
Gene Ontology Biological Process
- circadian regulation of gene expression [ISS]
- entrainment of circadian clock by photoperiod [ISS]
- mitotic cell cycle [TAS]
- negative regulation of transforming growth factor beta receptor signaling pathway [TAS]
- protein dephosphorylation [IMP, ISS]
- regulation of circadian rhythm [IMP]
- small molecule metabolic process [TAS]
- transforming growth factor beta receptor signaling pathway [TAS]
- triglyceride catabolic process [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
MYO6
DFNA22, DFNB37, RP3-472A9.1
myosin VI
GO Process (9)
GO Function (7)
GO Component (19)
Gene Ontology Biological Process
- DNA damage response, signal transduction by p53 class mediator [IDA]
- actin filament-based movement [ISS, NAS]
- endocytosis [IMP, ISS]
- intracellular protein transport [ISS]
- membrane organization [TAS]
- metabolic process [ISS, NAS]
- positive regulation of transcription from RNA polymerase II promoter [IMP]
- regulation of secretion [IMP]
- synaptic transmission [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- DNA-directed RNA polymerase II, holoenzyme [IDA]
- Golgi apparatus [IDA]
- cell cortex [ISS]
- clathrin-coated endocytic vesicle [IDA]
- cytoplasm [IDA, ISS]
- cytoplasmic membrane-bounded vesicle [IDA]
- cytosol [TAS]
- endocytic vesicle [ISS]
- extracellular vesicular exosome [IDA]
- filamentous actin [IDA, ISS]
- lysosomal membrane [TAS]
- membrane [IDA]
- nuclear membrane [IDA]
- nucleoplasm [IDA]
- nucleus [IDA]
- perinuclear region of cytoplasm [IDA, ISS]
- plasma membrane [TAS]
- ruffle [IDA]
- unconventional myosin complex [TAS]
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Ubiquitin-Independent Disassembly by a p97 AAA-ATPase Complex Drives PP1 Holoenzyme Formation.
The functional diversity of protein phosphatase-1 (PP1), with its countless substrates, relies on the ordered assembly of alternative PP1 holoenzymes. Here, we show that newly synthesized PP1 is first held by its partners SDS22 and inhibitor-3 (I3) in an inactive complex, which needs to be disassembled by the p97 AAA-ATPase to promote exchange to substrate specifiers. Unlike p97-mediated degradative processes ... [more]
Mol. Cell Dec. 15, 2017; 72(4);766-777.e6 [Pubmed: 30344098]
Throughput
- High Throughput
Curated By
- BioGRID