BAIT
PPP1CC
PP-1G, PP1C, PPP1G
protein phosphatase 1, catalytic subunit, gamma isozyme
GO Process (9)
GO Function (6)
GO Component (9)
Gene Ontology Biological Process
- circadian regulation of gene expression [ISS]
- entrainment of circadian clock by photoperiod [ISS]
- mitotic cell cycle [TAS]
- negative regulation of transforming growth factor beta receptor signaling pathway [TAS]
- protein dephosphorylation [IMP, ISS]
- regulation of circadian rhythm [IMP]
- small molecule metabolic process [TAS]
- transforming growth factor beta receptor signaling pathway [TAS]
- triglyceride catabolic process [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
THRAP3
TRAP150
thyroid hormone receptor associated protein 3
GO Process (9)
GO Function (10)
GO Component (5)
Gene Ontology Biological Process
- androgen receptor signaling pathway [IDA]
- intracellular steroid hormone receptor signaling pathway [IDA]
- mRNA stabilization [IMP]
- nuclear-transcribed mRNA catabolic process [IDA]
- positive regulation of mRNA splicing, via spliceosome [IMP]
- positive regulation of transcription from RNA polymerase II promoter [IDA]
- positive regulation of transcription, DNA-templated [IDA]
- regulation of alternative mRNA splicing, via spliceosome [IMP]
- transcription initiation from RNA polymerase II promoter [IDA]
Gene Ontology Molecular Function- RNA polymerase II transcription cofactor activity [IDA]
- ligand-dependent nuclear receptor transcription coactivator activity [NAS]
- phosphoprotein binding [IDA]
- poly(A) RNA binding [IDA]
- protein binding [IPI]
- receptor activity [IDA]
- thyroid hormone receptor binding [IDA]
- transcription coactivator activity [IDA]
- transcription cofactor activity [IDA]
- vitamin D receptor binding [NAS]
- RNA polymerase II transcription cofactor activity [IDA]
- ligand-dependent nuclear receptor transcription coactivator activity [NAS]
- phosphoprotein binding [IDA]
- poly(A) RNA binding [IDA]
- protein binding [IPI]
- receptor activity [IDA]
- thyroid hormone receptor binding [IDA]
- transcription coactivator activity [IDA]
- transcription cofactor activity [IDA]
- vitamin D receptor binding [NAS]
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Ubiquitin-Independent Disassembly by a p97 AAA-ATPase Complex Drives PP1 Holoenzyme Formation.
The functional diversity of protein phosphatase-1 (PP1), with its countless substrates, relies on the ordered assembly of alternative PP1 holoenzymes. Here, we show that newly synthesized PP1 is first held by its partners SDS22 and inhibitor-3 (I3) in an inactive complex, which needs to be disassembled by the p97 AAA-ATPase to promote exchange to substrate specifiers. Unlike p97-mediated degradative processes ... [more]
Mol. Cell Dec. 15, 2017; 72(4);766-777.e6 [Pubmed: 30344098]
Throughput
- High Throughput
Curated By
- BioGRID