BAIT

HDAC3

HD3, RPD3, RPD3-2
histone deacetylase 3
Homo sapiens
PREY

CCT5

CCT-epsilon, CCTE, HEL-S-69, TCP-1-epsilon
chaperonin containing TCP1, subunit 5 (epsilon)
Homo sapiens

Reconstituted Complex

An interaction is detected between purified proteins in vitro.

Publication

Assembly of the SMRT-histone deacetylase 3 repression complex requires the TCP-1 ring complex.

Guenther MG, Yu J, Kao GD, Yen TJ, Lazar MA

The acetylation of histone tails is a primary determinant of gene activity. Histone deacetylase 3 (HDAC3) requires the nuclear receptor corepressor SMRT for HDAC enzyme activity. Here we report that HDAC3 interacts with SMRT only after priming by cellular chaperones including the TCP-1 ring complex (TRiC), which is required for proper folding of HDAC3 in an ATP-dependent process. SMRT displaces ... [more]

Genes Dev. Dec. 15, 2002; 16(24);3130-5 [Pubmed: 12502735]

Throughput

  • Low Throughput

Related interactions

InteractionExperimental Evidence CodeDatasetThroughputScoreCurated ByNotes
CCT5 HDAC3
Affinity Capture-MS
Affinity Capture-MS

An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.

High0.7739BioGRID
3135654
HDAC3 CCT5
Affinity Capture-MS
Affinity Capture-MS

An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.

High1BioGRID
871994

Curated By

  • BioGRID