BAIT
PPP1CC
PP-1G, PP1C, PPP1G
protein phosphatase 1, catalytic subunit, gamma isozyme
GO Process (9)
GO Function (6)
GO Component (9)
Gene Ontology Biological Process
- circadian regulation of gene expression [ISS]
- entrainment of circadian clock by photoperiod [ISS]
- mitotic cell cycle [TAS]
- negative regulation of transforming growth factor beta receptor signaling pathway [TAS]
- protein dephosphorylation [IMP, ISS]
- regulation of circadian rhythm [IMP]
- small molecule metabolic process [TAS]
- transforming growth factor beta receptor signaling pathway [TAS]
- triglyceride catabolic process [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
RPS19
DBA, DBA1, S19
ribosomal protein S19
GO Process (26)
GO Function (6)
GO Component (8)
Gene Ontology Biological Process
- RNA metabolic process [TAS]
- SRP-dependent cotranslational protein targeting to membrane [TAS]
- cellular protein metabolic process [TAS]
- erythrocyte differentiation [IMP]
- gene expression [TAS]
- mRNA metabolic process [TAS]
- maturation of SSU-rRNA [IMP]
- maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [IMP]
- monocyte chemotaxis [IDA]
- negative regulation of respiratory burst involved in inflammatory response [IDA]
- nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [TAS]
- nucleolus organization [IMP]
- positive regulation of cellular component movement [TAS]
- positive regulation of respiratory burst involved in inflammatory response [IDA]
- protein tetramerization [IDA]
- rRNA processing [IMP]
- response to extracellular stimulus [TAS]
- ribosomal small subunit assembly [IMP]
- ribosomal small subunit biogenesis [IMP]
- translation [IC, TAS]
- translational elongation [TAS]
- translational initiation [TAS]
- translational termination [TAS]
- viral life cycle [TAS]
- viral process [TAS]
- viral transcription [TAS]
Gene Ontology Molecular Function
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Ubiquitin-Independent Disassembly by a p97 AAA-ATPase Complex Drives PP1 Holoenzyme Formation.
The functional diversity of protein phosphatase-1 (PP1), with its countless substrates, relies on the ordered assembly of alternative PP1 holoenzymes. Here, we show that newly synthesized PP1 is first held by its partners SDS22 and inhibitor-3 (I3) in an inactive complex, which needs to be disassembled by the p97 AAA-ATPase to promote exchange to substrate specifiers. Unlike p97-mediated degradative processes ... [more]
Mol. Cell Dec. 15, 2017; 72(4);766-777.e6 [Pubmed: 30344098]
Throughput
- High Throughput
Curated By
- BioGRID