BAIT
BRCA2
Fancd1, RAB163
breast cancer 2
GO Process (36)
GO Function (6)
GO Component (8)
Gene Ontology Biological Process
- DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator [IMP]
- DNA recombination [ISO]
- brain development [IMP]
- cell aging [IMP]
- cell proliferation [IMP]
- cellular response to DNA damage stimulus [IDA]
- centrosome duplication [IBA, ISO]
- chordate embryonic development [IMP]
- chromosome organization [IMP]
- cytokinesis [ISO]
- double-strand break repair [IMP, ISO]
- double-strand break repair via homologous recombination [IMP, ISO]
- female gonad development [IMP]
- hemopoiesis [IMP]
- histone H3 acetylation [ISO]
- histone H4 acetylation [ISO]
- homologous chromosome orientation involved in meiotic metaphase I plate congression [ISO]
- inner cell mass cell proliferation [IMP]
- intrinsic apoptotic signaling pathway in response to DNA damage [IGI]
- intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [IGI, IMP]
- male meiosis I [IMP]
- mammary gland development [ISO]
- multicellular organism growth [ISO]
- negative regulation of mammary gland epithelial cell proliferation [ISO]
- nucleotide-excision repair [ISO]
- oocyte maturation [IMP]
- positive regulation of mitotic cell cycle [IMP]
- positive regulation of transcription, DNA-templated [ISO]
- regulation of cell proliferation [IBA]
- regulation of cytokinesis [IMP]
- regulation of transcription, DNA-templated [IBA]
- replication fork protection [IMP]
- response to UV-C [IMP]
- response to X-ray [IMP]
- response to gamma radiation [IMP]
- spermatogenesis [IMP, ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
4930502E18RIK
Ct55, RP23-451C8.2
RIKEN cDNA 4930502E18 gene
GO Process (0)
GO Function (0)
GO Component (0)
Mus musculus
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
Novel BRCA2-interacting protein BJ-HCC-20A inhibits the induction of apoptosis in response to DNA damage.
The major hereditary breast cancer susceptibility gene BRCA2 is associated with familial breast and ovarian cancer. BRCA2 plays a role in DNA repair, transcription, cell cycle regulation, maintenance of genomic stability in response to DNA damage, centrosome regulation, and cytokinesis. To further understand the function of BRCA2, we used a yeast two-hybrid method and identified a novel BRCA2-interacting protein, BJ-HCC-20A, ... [more]
Cancer Sci. Apr. 01, 2008; 99(4);747-54 [Pubmed: 18307534]
Throughput
- Low Throughput
Curated By
- BioGRID