BAIT
GCG
GLP1, GLP2, GRPP
glucagon
GO Process (14)
GO Function (5)
GO Component (5)
Gene Ontology Biological Process
- G-protein coupled receptor signaling pathway [TAS]
- adenylate cyclase-modulating G-protein coupled receptor signaling pathway [IBA]
- cell proliferation [TAS]
- cellular protein metabolic process [TAS]
- cellular response to glucagon stimulus [TAS]
- energy reserve metabolic process [TAS]
- feeding behavior [TAS]
- negative regulation of apoptotic process [IBA]
- positive regulation of insulin secretion involved in cellular response to glucose stimulus [IBA]
- protein kinase A signaling [IBA]
- regulation of insulin secretion [TAS]
- response to starvation [IBA]
- signal transduction [TAS]
- small molecule metabolic process [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
ATP7A
MNK, RP23-186F4.3
ATPase, Cu++ transporting, alpha polypeptide
GO Process (47)
GO Function (6)
GO Component (16)
Gene Ontology Biological Process
- ATP catabolic process [IDA]
- ATP metabolic process [IMP]
- T-helper cell differentiation [IMP]
- blood vessel development [IMP]
- blood vessel remodeling [IMP]
- cartilage development [IMP]
- catecholamine metabolic process [IMP]
- cellular copper ion homeostasis [IGI, IMP, ISO]
- central nervous system neuron development [IMP]
- cerebellar Purkinje cell differentiation [IMP]
- collagen fibril organization [IMP]
- copper ion export [IDA, IMP]
- copper ion import [IMP]
- copper ion transport [IDA, IMP, ISO]
- dendrite morphogenesis [IMP]
- detoxification of copper ion [IMP]
- dopamine metabolic process [IMP]
- elastic fiber assembly [IMP]
- elastin biosynthetic process [IMP]
- epinephrine metabolic process [IMP]
- extracellular matrix organization [IMP]
- hair follicle morphogenesis [IMP]
- hindlimb morphogenesis [IMP]
- locomotory behavior [IMP]
- lung alveolus development [IMP]
- mitochondrion organization [IMP]
- negative regulation of metalloenzyme activity [IMP]
- negative regulation of neuron apoptotic process [IMP]
- neuron projection morphogenesis [IMP]
- norepinephrine biosynthetic process [IMP]
- norepinephrine metabolic process [IMP]
- peptidyl-lysine modification [IMP]
- pigmentation [IMP]
- plasma membrane copper ion transport [ISO]
- positive regulation of catalytic activity [IDA, IMP]
- positive regulation of metalloenzyme activity [IMP]
- positive regulation of oxidoreductase activity [ISO]
- pyramidal neuron development [IMP]
- regulation of gene expression [IMP]
- regulation of oxidative phosphorylation [IMP]
- release of cytochrome c from mitochondria [IMP]
- removal of superoxide radicals [IMP]
- response to copper ion [ISO]
- serotonin metabolic process [IMP]
- skin development [IMP]
- tryptophan metabolic process [IMP]
- tyrosine metabolic process [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- Golgi apparatus [IDA, ISO]
- basolateral plasma membrane [ISO]
- brush border membrane [ISO]
- cell [IGI]
- cytoplasmic vesicle [IDA]
- endoplasmic reticulum [ISO]
- integral component of membrane [ISO]
- late endosome [ISO]
- membrane [IDA, ISO]
- neuron projection [IDA]
- neuronal cell body [IDA]
- perinuclear region of cytoplasm [ISO]
- plasma membrane [IDA, ISO]
- secretory granule [ISO]
- trans-Golgi network [IDA, ISO]
- trans-Golgi network transport vesicle [ISO]
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Plasticity in the Glucagon Interactome Reveals Novel Proteins That Regulate Glucagon Secretion in α-TC1-6 Cells.
Glucagon is stored within the secretory granules of pancreatic alpha cells until stimuli trigger its release. The alpha cell secretory responses to the stimuli vary widely, possibly due to differences in experimental models or microenvironmental conditions. We hypothesized that the response of the alpha cell to various stimuli could be due to plasticity in the network of proteins that interact ... [more]
Front Endocrinol (Lausanne) Feb. 05, 2019; 9();792 [Pubmed: 30713523]
Throughput
- High Throughput
Curated By
- BioGRID