BAIT
GCG
GLP1, GLP2, GRPP
glucagon
GO Process (14)
GO Function (5)
GO Component (5)
Gene Ontology Biological Process
- G-protein coupled receptor signaling pathway [TAS]
- adenylate cyclase-modulating G-protein coupled receptor signaling pathway [IBA]
- cell proliferation [TAS]
- cellular protein metabolic process [TAS]
- cellular response to glucagon stimulus [TAS]
- energy reserve metabolic process [TAS]
- feeding behavior [TAS]
- negative regulation of apoptotic process [IBA]
- positive regulation of insulin secretion involved in cellular response to glucose stimulus [IBA]
- protein kinase A signaling [IBA]
- regulation of insulin secretion [TAS]
- response to starvation [IBA]
- signal transduction [TAS]
- small molecule metabolic process [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
MIF
GIF, Glif
macrophage migration inhibitory factor
GO Process (44)
GO Function (7)
GO Component (10)
Gene Ontology Biological Process
- DNA damage response, signal transduction by p53 class mediator [IMP]
- brain renin-angiotensin system [ISO]
- carboxylic acid metabolic process [ISO]
- cell aging [IMP]
- cell proliferation [ISO]
- cell surface receptor signaling pathway [ISO]
- drinking behavior [ISO]
- negative regulation of DNA damage response, signal transduction by p53 class mediator [IDA, ISO]
- negative regulation of apoptotic process [IDA, ISO]
- negative regulation of cell aging [ISO]
- negative regulation of cell cycle arrest [ISO]
- negative regulation of cellular protein metabolic process [IDA]
- negative regulation of gene expression [ISO]
- negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [ISO]
- negative regulation of mature B cell apoptotic process [IDA]
- negative regulation of myeloid cell apoptotic process [IMP]
- positive chemotaxis [ISO]
- positive regulation of B cell proliferation [ISO]
- positive regulation of ERK1 and ERK2 cascade [IDA, ISO]
- positive regulation of MAP kinase activity [IDA]
- positive regulation of acute inflammatory response [ISO]
- positive regulation of adaptive immune response [NAS]
- positive regulation of arachidonic acid secretion [IDA]
- positive regulation of axon regeneration [ISO]
- positive regulation of chemokine (C-X-C motif) ligand 2 production [IDA]
- positive regulation of cytokine secretion [ISO]
- positive regulation of fibroblast proliferation [IDA, ISO]
- positive regulation of glucose import [ISO]
- positive regulation of glycolytic process [ISO]
- positive regulation of immune response [ISO]
- positive regulation of lipopolysaccharide-mediated signaling pathway [IMP]
- positive regulation of myeloid leukocyte cytokine production involved in immune response [IMP]
- positive regulation of peptidyl-serine phosphorylation [IDA, ISO]
- positive regulation of peptidyl-tyrosine phosphorylation [IDA, ISO]
- positive regulation of phosphorylation [ISO]
- positive regulation of potassium ion transport [ISO]
- positive regulation of prostaglandin secretion involved in immune response [IMP]
- positive regulation of protein kinase A signaling [ISO]
- positive regulation of protein phosphorylation [IDA]
- positive regulation of smooth muscle cell migration [ISO]
- prostaglandin biosynthetic process [ISO]
- protein homotrimerization [ISO]
- regulation of cell proliferation [IMP]
- spermatogenesis [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Plasticity in the Glucagon Interactome Reveals Novel Proteins That Regulate Glucagon Secretion in α-TC1-6 Cells.
Glucagon is stored within the secretory granules of pancreatic alpha cells until stimuli trigger its release. The alpha cell secretory responses to the stimuli vary widely, possibly due to differences in experimental models or microenvironmental conditions. We hypothesized that the response of the alpha cell to various stimuli could be due to plasticity in the network of proteins that interact ... [more]
Front Endocrinol (Lausanne) Feb. 05, 2019; 9();792 [Pubmed: 30713523]
Throughput
- High Throughput
Curated By
- BioGRID