BAIT

SCAI

C9orf126, NET40
suppressor of cancer cell invasion
GO Process (3)
GO Function (2)
GO Component (2)

Gene Ontology Biological Process

Gene Ontology Molecular Function

Gene Ontology Cellular Component

Homo sapiens
PREY

REV3L

POLZ, REV3, RP5-1112D6.1
REV3-like, polymerase (DNA directed), zeta, catalytic subunit
GO Process (3)
GO Function (3)
GO Component (3)

Gene Ontology Biological Process

Gene Ontology Molecular Function

Gene Ontology Cellular Component

Homo sapiens

Affinity Capture-MS

An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.

Publication

Inhibition of RIF1 by SCAI Allows BRCA1-Mediated Repair.

Isobe SY, Nagao K, Nozaki N, Kimura H, Obuse C

DNA double-strand breaks (DSBs) are repaired by either the homology-directed repair (HDR) or the non-homologous end-joining (NHEJ) pathway. RIF1 (RAP1-interacting factor homolog) was recently shown to stimulate NHEJ through an interaction with 53BP1 (p53-binding protein 1) phosphorylated at S/TQ sites, but the molecular mechanism underlying pathway choice remains unclear. Here, we show that SCAI (suppressor of cancer cell invasion) binds ... [more]

Cell Rep Dec. 11, 2016; 20(2);297-307 [Pubmed: 28700933]

Throughput

  • Low Throughput

Curated By

  • BioGRID