BAIT
GCG
GLP1, GLP2, GRPP
glucagon
GO Process (14)
GO Function (5)
GO Component (5)
Gene Ontology Biological Process
- G-protein coupled receptor signaling pathway [TAS]
- adenylate cyclase-modulating G-protein coupled receptor signaling pathway [IBA]
- cell proliferation [TAS]
- cellular protein metabolic process [TAS]
- cellular response to glucagon stimulus [TAS]
- energy reserve metabolic process [TAS]
- feeding behavior [TAS]
- negative regulation of apoptotic process [IBA]
- positive regulation of insulin secretion involved in cellular response to glucose stimulus [IBA]
- protein kinase A signaling [IBA]
- regulation of insulin secretion [TAS]
- response to starvation [IBA]
- signal transduction [TAS]
- small molecule metabolic process [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
USP14
2610005K12Rik, 2610037B11Rik, AW107924, C78769, ax, nmf375
ubiquitin specific peptidase 14
GO Process (8)
GO Function (5)
GO Component (6)
Gene Ontology Biological Process
- negative regulation of ER-associated ubiquitin-dependent protein catabolic process [ISO]
- negative regulation of endopeptidase activity [ISO]
- proteasome-mediated ubiquitin-dependent protein catabolic process [IBA]
- protein deubiquitination [IBA, ISO]
- proteolysis [ISO]
- regulation of chemotaxis [ISO]
- regulation of proteasomal protein catabolic process [IBA, ISO]
- synaptic transmission [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Plasticity in the Glucagon Interactome Reveals Novel Proteins That Regulate Glucagon Secretion in α-TC1-6 Cells.
Glucagon is stored within the secretory granules of pancreatic alpha cells until stimuli trigger its release. The alpha cell secretory responses to the stimuli vary widely, possibly due to differences in experimental models or microenvironmental conditions. We hypothesized that the response of the alpha cell to various stimuli could be due to plasticity in the network of proteins that interact ... [more]
Front Endocrinol (Lausanne) Feb. 05, 2019; 9();792 [Pubmed: 30713523]
Throughput
- High Throughput
Curated By
- BioGRID