BAIT
GCG
GLP1, GLP2, GRPP
glucagon
GO Process (14)
GO Function (5)
GO Component (5)
Gene Ontology Biological Process
- G-protein coupled receptor signaling pathway [TAS]
- adenylate cyclase-modulating G-protein coupled receptor signaling pathway [IBA]
- cell proliferation [TAS]
- cellular protein metabolic process [TAS]
- cellular response to glucagon stimulus [TAS]
- energy reserve metabolic process [TAS]
- feeding behavior [TAS]
- negative regulation of apoptotic process [IBA]
- positive regulation of insulin secretion involved in cellular response to glucose stimulus [IBA]
- protein kinase A signaling [IBA]
- regulation of insulin secretion [TAS]
- response to starvation [IBA]
- signal transduction [TAS]
- small molecule metabolic process [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
PKN1
DBK, F730027O18Rik, PAK1, PRK1, Pkn, Prkcl1, Stk3
protein kinase N1
GO Process (15)
GO Function (12)
GO Component (7)
Gene Ontology Biological Process
- B cell apoptotic process [IMP]
- B cell homeostasis [IMP]
- epithelial cell migration [ISO]
- histone H3-T11 phosphorylation [ISO]
- hyperosmotic response [IDA]
- negative regulation of B cell proliferation [IMP]
- negative regulation of protein kinase activity [IMP]
- negative regulation of protein phosphorylation [IMP]
- protein phosphorylation [IMP, ISO]
- regulation of cell motility [ISO]
- regulation of germinal center formation [IMP]
- regulation of immunoglobulin production [IMP]
- regulation of transcription from RNA polymerase II promoter [ISO]
- renal system process [IMP]
- spleen development [IMP]
Gene Ontology Molecular Function- GTP-Rho binding [ISO]
- Rac GTPase binding [ISO]
- androgen receptor binding [ISO]
- chromatin binding [ISO]
- histone binding [ISO]
- histone deacetylase binding [ISO]
- histone kinase activity (H3-T11 specific) [ISO]
- ligand-dependent nuclear receptor transcription coactivator activity [ISO]
- protein binding [IPI]
- protein kinase C binding [ISO]
- protein kinase activity [IMP, ISO]
- protein serine/threonine kinase activity [ISO]
- GTP-Rho binding [ISO]
- Rac GTPase binding [ISO]
- androgen receptor binding [ISO]
- chromatin binding [ISO]
- histone binding [ISO]
- histone deacetylase binding [ISO]
- histone kinase activity (H3-T11 specific) [ISO]
- ligand-dependent nuclear receptor transcription coactivator activity [ISO]
- protein binding [IPI]
- protein kinase C binding [ISO]
- protein kinase activity [IMP, ISO]
- protein serine/threonine kinase activity [ISO]
Gene Ontology Cellular Component
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Plasticity in the Glucagon Interactome Reveals Novel Proteins That Regulate Glucagon Secretion in α-TC1-6 Cells.
Glucagon is stored within the secretory granules of pancreatic alpha cells until stimuli trigger its release. The alpha cell secretory responses to the stimuli vary widely, possibly due to differences in experimental models or microenvironmental conditions. We hypothesized that the response of the alpha cell to various stimuli could be due to plasticity in the network of proteins that interact ... [more]
Front Endocrinol (Lausanne) Feb. 05, 2019; 9();792 [Pubmed: 30713523]
Throughput
- High Throughput
Curated By
- BioGRID