BAIT
RAD51
BRCC5, HRAD51, HsRad51, HsT16930, MRMV2, RAD51A, RECA
RAD51 recombinase
GO Process (16)
GO Function (8)
GO Component (10)
Gene Ontology Biological Process
- ATP catabolic process [IDA]
- DNA recombinase assembly [TAS]
- DNA recombination [TAS]
- DNA repair [TAS]
- DNA unwinding involved in DNA replication [IDA]
- cellular response to DNA damage stimulus [IDA]
- cellular response to camptothecin [IDA]
- cellular response to ionizing radiation [IDA]
- double-strand break repair [TAS]
- double-strand break repair via homologous recombination [IDA, IMP, TAS]
- meiotic nuclear division [ISS]
- mitotic recombination [TAS]
- positive regulation of DNA ligation [IDA]
- protein homooligomerization [IPI]
- reciprocal meiotic recombination [TAS]
- regulation of double-strand break repair via homologous recombination [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
EVL
RNB6
Enah/Vasp-like
GO Process (9)
GO Function (3)
GO Component (5)
Gene Ontology Biological Process
- actin filament organization [TAS]
- actin polymerization or depolymerization [ISS]
- axon guidance [TAS]
- cell surface receptor signaling pathway [NAS]
- negative regulation of epithelial cell migration [IMP]
- negative regulation of ruffle assembly [IMP]
- nervous system development [NAS]
- organ morphogenesis [NAS]
- positive regulation of stress fiber assembly [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Reconstituted Complex
An interaction is detected between purified proteins in vitro.
Publication
Biochemical analysis of the human ENA/VASP-family proteins, MENA, VASP and EVL, in homologous recombination.
MENA, VASP and EVL are members of the ENA/VASP family of proteins and are involved in cytoplasmic actin remodeling. Previously, we found that EVL directly interacts with RAD51, an essential protein in the homologous recombinational repair of double-strand breaks (DSBs) and stimulates the RAD51-mediated recombination reactions in vitro. The EVL-knockdown MCF7 cells exhibited a clear reduction in RAD51-foci formation, suggesting ... [more]
J. Biochem. Jun. 01, 2011; 149(6);721-9 [Pubmed: 21398369]
Throughput
- Low Throughput
Related interactions
Curated By
- BioGRID