SNAI2
Gene Ontology Biological Process
- Notch signaling pathway [IMP]
- canonical Wnt signaling pathway [IMP]
- cell migration involved in endocardial cushion formation [ISS]
- cellular response to epidermal growth factor stimulus [IDA]
- desmosome disassembly [IMP]
- epithelial to mesenchymal transition [IMP]
- epithelial to mesenchymal transition involved in endocardial cushion formation [ISS]
- epithelium development [ISS]
- negative regulation of DNA damage response, signal transduction by p53 class mediator [IMP]
- negative regulation of anoikis [IMP]
- negative regulation of canonical Wnt signaling pathway [IDA, IMP]
- negative regulation of catenin import into nucleus [IDA]
- negative regulation of cell adhesion mediated by integrin [IC]
- negative regulation of cell-cell adhesion by negative regulation of transcription from RNA polymerase II promoter [IMP]
- negative regulation of chondrocyte differentiation [IMP]
- negative regulation of extrinsic apoptotic signaling pathway in absence of ligand [ISS]
- negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage [IMP]
- negative regulation of keratinocyte proliferation [IDA]
- negative regulation of transcription from RNA polymerase II promoter [IDA, IMP]
- negative regulation of vitamin D biosynthetic process [IDA]
- negative regulation of vitamin D receptor signaling pathway [IDA]
- neural crest cell development [IMP]
- osteoblast differentiation [IEP]
- pigmentation [IMP]
- positive regulation of cell migration [IMP]
- regulation of chemokine production [IMP]
- regulation of osteoblast differentiation [IMP]
- regulation of tight junction assembly [IMP]
- sensory perception of sound [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
PIAS1
Gene Ontology Biological Process
- JAK-STAT cascade [TAS]
- androgen receptor signaling pathway [NAS]
- cytokine-mediated signaling pathway [TAS]
- interferon-gamma-mediated signaling pathway [TAS]
- positive regulation of proteasomal ubiquitin-dependent protein catabolic process [ISS]
- positive regulation of protein sumoylation [IDA]
- positive regulation of transcription, DNA-templated [NAS]
- protein sumoylation [ISS]
- regulation of cell proliferation [ISS]
- regulation of interferon-gamma-mediated signaling pathway [TAS]
Gene Ontology Molecular Function
Reconstituted Complex
An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator.
Publication
Hypoxia-induced Slug SUMOylation enhances lung cancer metastasis.
The Slug-E-cadherin axis plays a critical role in non-small-cell lung cancers (NSCLCs) where aberrant upregulation of Slug promotes cancer metastasis. Now, the post-translational modifications of Slug and their regulation mechanisms still remain unclear in lung cancer. Hence, exploring the protein linkage map of Slug is of great interest for investigating the scenario of how Slug protein is regulated in lung ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID