An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.

Publication

Cytoplasmic Metadherin (MTDH) provides survival advantage under conditions of stress by acting as RNA-binding protein.

Meng X, Zhu D, Yang S, Wang X, Xiong Z, Zhang Y, Brachova P, Leslie KK

Overexpression of metadherin (MTDH) has been documented in many solid tumors and is implicated in metastasis and chemoresistance. MTDH has been detected at the plasma membrane as well as in the cytoplasm and nucleus, and the function of MTDH in these locales remains under investigation. In the nucleus, MTDH acts as a transcription co-factor to induce expression of chemoresistance-associated genes. ... [more]

J. Biol. Chem. Feb. 10, 2012; 287(7);4485-91 [Pubmed: 22199357]

Throughput

High Throughput

Related interactions

Interaction	Experimental Evidence Code	Dataset	Throughput	Score	Curated By	Notes
LRRC59 MTDH	Proximity Label-MS Proximity Label-MS An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods.	Go CD (2021)	High	21.59	BioGRID	2995229
LRRC59 MTDH	Proximity Label-MS Proximity Label-MS An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods.	Hannigan MM (2020)	High	-	BioGRID	-

Curated By

BioGRID

Interaction Summary

MTDH

Gene Ontology Biological Process

Gene Ontology Molecular Function

NF-kappaB binding [IPI]RNA polymerase II transcription factor binding [IPI]double-stranded RNA binding [IDA]poly(A) RNA binding [IDA]protein binding [IPI]transcription coactivator activity [IMP]

Gene Ontology Cellular Component

LRRC59