BAIT
MTDH
3D3, AEG-1, AEG1, LYRIC, LYRIC/3D3
metadherin
GO Process (8)
GO Function (6)
GO Component (10)
Gene Ontology Biological Process
- lipopolysaccharide-mediated signaling pathway [IMP]
- negative regulation of apoptotic process [IDA]
- negative regulation of transcription from RNA polymerase II promoter [IDA]
- positive regulation of I-kappaB kinase/NF-kappaB signaling [IDA]
- positive regulation of NF-kappaB transcription factor activity [IDA]
- positive regulation of angiogenesis [IDA]
- positive regulation of autophagy [IDA]
- positive regulation of protein kinase B signaling [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
CTGF
CCN2, HCS24, IGFBP8, NOV2
connective tissue growth factor
GO Process (13)
GO Function (3)
GO Component (4)
Gene Ontology Biological Process
- cell adhesion [IBA]
- cell-cell signaling [IBA]
- cellular lipid metabolic process [TAS]
- epidermis development [TAS]
- gene expression [TAS]
- negative regulation of cell death [IBA]
- positive regulation of ERK1 and ERK2 cascade [IDA]
- positive regulation of JNK cascade [IDA]
- positive regulation of cell differentiation [IDA]
- positive regulation of stress fiber assembly [IDA]
- response to wounding [TAS]
- small molecule metabolic process [TAS]
- transcription initiation from RNA polymerase II promoter [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Protein-RNA
An interaction is detected between and protein and an RNA in vitro.
Publication
Cytoplasmic Metadherin (MTDH) provides survival advantage under conditions of stress by acting as RNA-binding protein.
Overexpression of metadherin (MTDH) has been documented in many solid tumors and is implicated in metastasis and chemoresistance. MTDH has been detected at the plasma membrane as well as in the cytoplasm and nucleus, and the function of MTDH in these locales remains under investigation. In the nucleus, MTDH acts as a transcription co-factor to induce expression of chemoresistance-associated genes. ... [more]
J. Biol. Chem. Feb. 10, 2012; 287(7);4485-91 [Pubmed: 22199357]
Throughput
- High Throughput
Additional Notes
- MTDH-mRNA interactions increased by dual PI3K/mTOR inhibitor BEZ
- mRNAs only detected in the MTDH pulldown of BEZ-treated cells (PI3K/mTOR inhibitor)
Curated By
- BioGRID