BAIT
MTDH
3D3, AEG-1, AEG1, LYRIC, LYRIC/3D3
metadherin
GO Process (8)
GO Function (6)
GO Component (10)
Gene Ontology Biological Process
- lipopolysaccharide-mediated signaling pathway [IMP]
- negative regulation of apoptotic process [IDA]
- negative regulation of transcription from RNA polymerase II promoter [IDA]
- positive regulation of I-kappaB kinase/NF-kappaB signaling [IDA]
- positive regulation of NF-kappaB transcription factor activity [IDA]
- positive regulation of angiogenesis [IDA]
- positive regulation of autophagy [IDA]
- positive regulation of protein kinase B signaling [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
ERCC2
COFS2, EM9, TFIIH, TTD, XPD
excision repair cross-complementation group 2
GO Process (28)
GO Function (7)
GO Component (7)
Gene Ontology Biological Process
- 7-methylguanosine mRNA capping [TAS]
- ATP catabolic process [IDA, TAS]
- DNA duplex unwinding [IDA]
- DNA repair [TAS]
- UV protection [IGI]
- apoptotic process [IMP]
- chromosome segregation [IMP]
- gene expression [TAS]
- hair cell differentiation [IMP]
- nucleotide-excision repair [IGI, NAS, TAS]
- nucleotide-excision repair, DNA damage removal [TAS]
- nucleotide-excision repair, DNA incision [IMP]
- positive regulation of transcription from RNA polymerase II promoter [IDA]
- positive regulation of transcription, DNA-templated [IDA]
- positive regulation of viral transcription [TAS]
- protein phosphorylation [IDA]
- regulation of mitotic cell cycle phase transition [IMP]
- response to oxidative stress [IMP]
- small molecule metabolic process [TAS]
- termination of RNA polymerase I transcription [TAS]
- transcription elongation from RNA polymerase I promoter [TAS]
- transcription elongation from RNA polymerase II promoter [TAS]
- transcription from RNA polymerase I promoter [TAS]
- transcription from RNA polymerase II promoter [IDA, TAS]
- transcription initiation from RNA polymerase I promoter [TAS]
- transcription initiation from RNA polymerase II promoter [TAS]
- transcription-coupled nucleotide-excision repair [IDA, TAS]
- viral process [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Protein-RNA
An interaction is detected between and protein and an RNA in vitro.
Publication
Cytoplasmic Metadherin (MTDH) provides survival advantage under conditions of stress by acting as RNA-binding protein.
Overexpression of metadherin (MTDH) has been documented in many solid tumors and is implicated in metastasis and chemoresistance. MTDH has been detected at the plasma membrane as well as in the cytoplasm and nucleus, and the function of MTDH in these locales remains under investigation. In the nucleus, MTDH acts as a transcription co-factor to induce expression of chemoresistance-associated genes. ... [more]
J. Biol. Chem. Feb. 10, 2012; 287(7);4485-91 [Pubmed: 22199357]
Throughput
- High Throughput
Additional Notes
- mRNAs only detected in the MTDH pulldown of BEZ-treated cells (PI3K/mTOR inhibitor)
Curated By
- BioGRID