Protein-RNA

An interaction is detected between and protein and an RNA in vitro.

Publication

Cytoplasmic Metadherin (MTDH) provides survival advantage under conditions of stress by acting as RNA-binding protein.

Meng X, Zhu D, Yang S, Wang X, Xiong Z, Zhang Y, Brachova P, Leslie KK

Overexpression of metadherin (MTDH) has been documented in many solid tumors and is implicated in metastasis and chemoresistance. MTDH has been detected at the plasma membrane as well as in the cytoplasm and nucleus, and the function of MTDH in these locales remains under investigation. In the nucleus, MTDH acts as a transcription co-factor to induce expression of chemoresistance-associated genes. ... [more]

J. Biol. Chem. Feb. 10, 2012; 287(7);4485-91 [Pubmed: 22199357]

Throughput

  • High Throughput

Additional Notes

  • mRNAs only detected in the MTDH pulldown of BEZ-treated cells (PI3K/mTOR inhibitor)

Curated By

  • BioGRID