BAIT
UBE3C
HECTH2, tcag7.998
ubiquitin protein ligase E3C
GO Process (2)
GO Function (2)
GO Component (3)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Homo sapiens
PREY
P4HB
DSI, ERBA2L, GIT, P4Hbeta, PDI, PDIA1, PHDB, PO4DB, PO4HB, PROHB
prolyl 4-hydroxylase, beta polypeptide
GO Process (8)
GO Function (4)
GO Component (7)
Gene Ontology Biological Process
- cellular response to hypoxia [IMP]
- extracellular matrix organization [TAS]
- lipoprotein metabolic process [TAS]
- peptidyl-proline hydroxylation to 4-hydroxy-L-proline [IDA]
- protein folding [IBA]
- regulation of oxidative stress-induced intrinsic apoptotic signaling pathway [IMP]
- response to endoplasmic reticulum stress [IMP]
- small molecule metabolic process [TAS]
Gene Ontology Molecular Function
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Ubiquitin-protein ligase E3C maintains non-small-cell lung cancer stemness by targeting AHNAK-p53 complex.
Cancer stem-like cells (CSCs) are regarded as sources of tumorigenesis, metastasis, and drug resistance, which limits current cancer therapies. Elucidating the molecular modes governing CSC properties is necessary to optimize therapeutic approaches. In this study, we discovered that ubiquitin-protein ligase E3C (UBE3C)-mediated ubiquitination is a key posttranslational mechanism involved in maintaining CSC properties of non-small-cell lung cancer (NSCLC). UBE3C was ... [more]
Cancer Lett. Feb. 28, 2019; 443();125-134 [Pubmed: 30503554]
Throughput
- High Throughput
Curated By
- BioGRID