BAR-1
Gene Ontology Biological Process
- Ras protein signal transduction [IGI]
- Wnt signaling pathway [IMP]
- cell adhesion [TAS]
- cell fate specification [IMP]
- hermaphrodite genitalia development [IMP]
- locomotion [IMP]
- mating behavior [IMP]
- morphogenesis of an epithelium [IMP]
- oviposition [IMP]
- positive regulation of transcription from RNA polymerase II promoter [IDA, IMP]
- positive regulation of vulval development [IMP]
- receptor-mediated endocytosis [IMP]
- regulation of backward locomotion [IMP]
- regulation of cell fate specification [IMP]
- regulation of cell migration [IMP]
- regulation of vulval development [IGI, IMP]
Gene Ontology Molecular Function
MEL-11
Gene Ontology Biological Process
Gene Ontology Cellular Component
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
A combined binary interaction and phenotypic map of C. elegans cell polarity proteins.
The establishment of cell polarity is an essential process for the development of multicellular organisms and the functioning of cells and tissues. Here, we combine large-scale protein interaction mapping with systematic phenotypic profiling to study the network of physical interactions that underlies polarity establishment and maintenance in the nematode Caenorhabditis elegans. Using a fragment-based yeast two-hybrid strategy, we identified 439 interactions ... [more]
Throughput
- High Throughput
Additional Notes
- Fragment bait constructs
Related interactions
Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
---|---|---|---|---|---|---|
BAR-1 MEL-11 | Negative Genetic Negative Genetic Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores. | High | 4.7857 | BioGRID | 466030 |
Curated By
- BioGRID