BAIT
CD36
FAT, GPIV, Scarb3
CD36 antigen
GO Process (51)
GO Function (10)
GO Component (14)
Gene Ontology Biological Process
- apoptotic cell clearance [IMP]
- cGMP-mediated signaling [ISO]
- cell surface receptor signaling pathway [IDA]
- cellular response to bacterial lipopeptide [IMP]
- cellular response to hydroperoxide [IMP]
- cellular response to lipopolysaccharide [IMP]
- cellular response to lipoteichoic acid [IDA, IMP]
- cholesterol transport [IMP]
- defense response to Gram-positive bacterium [IMP]
- fatty acid metabolic process [ISO]
- fatty acid oxidation [ISO]
- fatty acid transport [ISO]
- lipid storage [IMP, ISO]
- lipoprotein transport [IMP, ISO]
- long-chain fatty acid import [ISO]
- long-chain fatty acid metabolic process [ISO]
- long-chain fatty acid transport [ISO]
- low-density lipoprotein particle clearance [IMP, ISO]
- low-density lipoprotein particle mediated signaling [IDA]
- negative regulation of angiogenesis [ISO]
- negative regulation of gene expression [IMP]
- negative regulation of growth of symbiont in host [IMP]
- negative regulation of systemic arterial blood pressure [ISO]
- negative regulation of transcription factor import into nucleus [IMP]
- negative regulation of transcription from RNA polymerase II promoter [IMP]
- nitric oxide mediated signal transduction [ISO]
- pattern recognition receptor signaling pathway [IMP]
- phagocytosis, recognition [IDA]
- plasma lipoprotein particle clearance [IMP]
- plasma membrane long-chain fatty acid transport [ISO]
- positive regulation of I-kappaB kinase/NF-kappaB signaling [IMP]
- positive regulation of MAPK cascade [IMP]
- positive regulation of blood coagulation [IMP]
- positive regulation of blood microparticle formation [IMP]
- positive regulation of cell-matrix adhesion [ISO]
- positive regulation of cholesterol storage [IMP]
- positive regulation of cytokine secretion [ISO]
- positive regulation of interleukin-12 production [IMP]
- positive regulation of interleukin-6 production [IMP]
- positive regulation of macrophage cytokine production [IMP]
- positive regulation of macrophage derived foam cell differentiation [IMP, ISO]
- positive regulation of peptidyl-tyrosine phosphorylation [IDA]
- positive regulation of phagocytosis, engulfment [IDA, IMP]
- positive regulation of reactive oxygen species metabolic process [IMP]
- positive regulation of tumor necrosis factor production [IMP]
- receptor-mediated endocytosis [IMP]
- regulation of removal of superoxide radicals [IMP]
- regulation of transcription from RNA polymerase II promoter in response to oxidative stress [IC]
- response to mechanical stimulus [ISO]
- signal transduction [ISO]
- triglyceride metabolic process [ISO]
Gene Ontology Molecular Function- high-density lipoprotein particle binding [IDA]
- lipid binding [ISO, ISS]
- lipoprotein particle binding [ISO]
- lipoteichoic acid receptor activity [IMP]
- low-density lipoprotein particle binding [IMP, ISO]
- low-density lipoprotein receptor activity [IMP, ISO]
- oleic acid binding [ISO]
- protein binding [IPI]
- thrombospondin receptor activity [ISO]
- transforming growth factor beta binding [ISO]
- high-density lipoprotein particle binding [IDA]
- lipid binding [ISO, ISS]
- lipoprotein particle binding [ISO]
- lipoteichoic acid receptor activity [IMP]
- low-density lipoprotein particle binding [IMP, ISO]
- low-density lipoprotein receptor activity [IMP, ISO]
- oleic acid binding [ISO]
- protein binding [IPI]
- thrombospondin receptor activity [ISO]
- transforming growth factor beta binding [ISO]
Gene Ontology Cellular Component
- Golgi apparatus [IDA]
- apical part of cell [ISO]
- caveola [ISO]
- cell surface [ISO, ISS]
- endoplasmic reticulum [ISO]
- external side of plasma membrane [IDA]
- extracellular space [ISO]
- intracellular [ISO]
- intracellular membrane-bounded organelle [ISO]
- membrane raft [IDA]
- mitochondrion [ISO]
- plasma membrane [IDA, ISO]
- protein complex [ISO]
- sarcolemma [ISO]
Mus musculus
PREY
FYN
AI448320, AW552119
Fyn proto-oncogene
GO Process (29)
GO Function (17)
GO Component (10)
Gene Ontology Biological Process
- T cell receptor signaling pathway [IBA, ISO]
- activated T cell proliferation [IMP]
- cell surface receptor signaling pathway [IDA]
- cellular response to peptide hormone stimulus [IBA]
- cellular response to platelet-derived growth factor stimulus [IDA]
- cellular response to transforming growth factor beta stimulus [IGI]
- dendrite morphogenesis [IMP]
- detection of mechanical stimulus involved in sensory perception of pain [IMP]
- forebrain development [IGI, IMP]
- innate immune response [IBA]
- myelination [TAS]
- negative regulation of extrinsic apoptotic signaling pathway in absence of ligand [ISO]
- negative regulation of gene expression [IMP]
- negative regulation of neuron apoptotic process [ISO]
- negative regulation of protein catabolic process [IMP]
- neuron migration [IGI, IMP]
- peptidyl-tyrosine autophosphorylation [IBA]
- peptidyl-tyrosine phosphorylation [IDA, IMP, ISO]
- positive regulation of I-kappaB kinase/NF-kappaB signaling [IGI]
- positive regulation of neuron projection development [IGI]
- positive regulation of phosphatidylinositol 3-kinase signaling [ISO]
- positive regulation of protein localization to nucleus [IDA]
- protein autophosphorylation [IDA, ISO]
- protein phosphorylation [IMP]
- regulation of apoptotic process [IBA]
- regulation of cell proliferation [IBA]
- regulation of cell shape [IDA]
- response to ethanol [IGI]
- transmembrane receptor protein tyrosine kinase signaling pathway [IBA]
Gene Ontology Molecular Function- CD4 receptor binding [ISO]
- CD8 receptor binding [ISO]
- G-protein coupled receptor binding [IPI]
- T cell receptor binding [ISO]
- ephrin receptor binding [ISO]
- glycoprotein binding [ISO]
- growth factor receptor binding [ISO]
- ion channel binding [IPI]
- non-membrane spanning protein tyrosine kinase activity [IBA]
- peptide hormone receptor binding [ISO]
- phosphatidylinositol 3-kinase binding [ISO]
- protein binding [IPI]
- protein complex binding [ISO]
- protein kinase activity [IDA, ISO]
- protein tyrosine kinase activity [IDA, ISO]
- receptor binding [ISO]
- tubulin binding [IDA]
- CD4 receptor binding [ISO]
- CD8 receptor binding [ISO]
- G-protein coupled receptor binding [IPI]
- T cell receptor binding [ISO]
- ephrin receptor binding [ISO]
- glycoprotein binding [ISO]
- growth factor receptor binding [ISO]
- ion channel binding [IPI]
- non-membrane spanning protein tyrosine kinase activity [IBA]
- peptide hormone receptor binding [ISO]
- phosphatidylinositol 3-kinase binding [ISO]
- protein binding [IPI]
- protein complex binding [ISO]
- protein kinase activity [IDA, ISO]
- protein tyrosine kinase activity [IDA, ISO]
- receptor binding [ISO]
- tubulin binding [IDA]
Gene Ontology Cellular Component
Mus musculus
Reconstituted Complex
An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator.
Publication
Regulation of AMPK activation by CD36 links fatty acid uptake to ?-oxidation.
Increases in muscle energy needs activate AMPK and induce sarcolemmal recruitment of the fatty acid (FA) translocase CD36. The resulting rises in FA uptake and FA oxidation are tightly correlated, suggesting coordinated regulation. We explored the possibility that membrane CD36 signaling might influence AMPK activation. We show, using several cell types, including myocytes, that CD36 expression suppresses AMPK, keeping it ... [more]
Diabetes Feb. 01, 2015; 64(2);353-9 [Pubmed: 25157091]
Throughput
- Low Throughput
Curated By
- BioGRID