BAIT
APOB
AI315052, Apo B-100, apob-100, apob-48, mCG_129875
apolipoprotein B
GO Process (26)
GO Function (6)
GO Component (15)
Gene Ontology Biological Process
- artery morphogenesis [IGI]
- cholesterol efflux [IGI]
- cholesterol homeostasis [IGI, IMP, ISO]
- cholesterol metabolic process [ISO]
- cholesterol transport [IMP, ISO]
- fertilization [IMP]
- in utero embryonic development [IMP]
- lipid catabolic process [IMP]
- lipid metabolic process [IDA, IGI, IMP, ISO]
- lipoprotein biosynthetic process [IGI]
- lipoprotein catabolic process [IGI]
- lipoprotein metabolic process [IGI, IMP]
- lipoprotein transport [IGI, IMP]
- low-density lipoprotein particle clearance [ISO]
- low-density lipoprotein particle remodeling [ISO]
- nervous system development [IMP]
- positive regulation of cholesterol storage [ISO]
- positive regulation of lipid storage [ISO]
- positive regulation of macrophage derived foam cell differentiation [ISO]
- post-embryonic development [IMP]
- regulation of cholesterol biosynthetic process [IMP]
- response to carbohydrate [ISO]
- sperm motility [IMP]
- spermatogenesis [IMP]
- triglyceride catabolic process [IMP, ISO]
- triglyceride mobilization [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- Golgi apparatus [ISO]
- actin cytoskeleton [ISO]
- chylomicron [ISO]
- cytoplasm [ISO]
- endoplasmic reticulum [IDA]
- extracellular space [ISO]
- extracellular vesicular exosome [ISO]
- intermediate-density lipoprotein particle [ISO]
- intracellular membrane-bounded organelle [ISO]
- low-density lipoprotein particle [ISO]
- mature chylomicron [ISO]
- plasma membrane [ISO]
- very-low-density lipoprotein particle [ISO]
- vesicle lumen [ISO]
- vesicle membrane [ISO]
Mus musculus
PREY
APOA4
Apoa-4
apolipoprotein A-IV
GO Process (28)
GO Function (8)
GO Component (7)
Gene Ontology Biological Process
- cholesterol biosynthetic process [IBA]
- cholesterol efflux [IBA, ISO]
- cholesterol homeostasis [IBA, ISO]
- cholesterol metabolic process [ISO]
- high-density lipoprotein particle assembly [IBA]
- hydrogen peroxide catabolic process [ISO]
- innate immune response in mucosa [IMP, ISO]
- leukocyte cell-cell adhesion [ISO]
- lipid homeostasis [ISO]
- lipid transport [ISO]
- lipoprotein metabolic process [IBA]
- multicellular organismal lipid catabolic process [ISO]
- negative regulation of plasma lipoprotein particle oxidation [ISO]
- neuron projection regeneration [IBA]
- phosphatidylcholine metabolic process [IBA, ISO]
- phospholipid efflux [IBA, ISO]
- positive regulation of cholesterol esterification [IBA, ISO]
- positive regulation of fatty acid biosynthetic process [IBA, ISO]
- positive regulation of lipoprotein lipase activity [IBA, ISO]
- positive regulation of triglyceride catabolic process [IBA, ISO]
- protein-lipid complex assembly [ISO]
- regulation of cholesterol transport [ISO]
- regulation of intestinal cholesterol absorption [IMP]
- removal of superoxide radicals [ISO]
- response to lipid hydroperoxide [ISO]
- reverse cholesterol transport [IBA, ISO]
- triglyceride homeostasis [IBA]
- very-low-density lipoprotein particle remodeling [IBA, ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Co-fractionation
Interaction inferred from the presence of two or more protein subunits in a partially purified protein preparation. If co-fractionation is demonstrated between 3 or more proteins, then add them as a complex.
Publication
Site-specific mutagenesis demonstrates that cysteine 4326 of apolipoprotein B is required for covalent linkage with apolipoprotein (a) in vivo.
In the formation of the lipoprotein(a) (Lp(a)) particle, apolipoprotein(a) (apo(a)) and apolipoprotein B (apoB) are covalently linked via a disulfide bond in both humans and human-apo(a)/apoB transgenic mice. Studies based upon fluorescent labeling of free cysteine residues have suggested that cysteine 3734 of the 4 carboxyl-terminal cysteines of apoB (Cys-3734, Cys-3890, Cys-4190, and Cys-4326) is the most likely candidate to ... [more]
J. Biol. Chem. Oct. 13, 1995; 270(41);23914-7 [Pubmed: 7592581]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| APOB APOA4 | Co-fractionation Co-fractionation Interaction inferred from the presence of two or more protein subunits in a partially purified protein preparation. If co-fractionation is demonstrated between 3 or more proteins, then add them as a complex. | High | 0.87 | BioGRID | 2677771 |
Curated By
- BioGRID