COPS5
Gene Ontology Biological Process
- cullin deneddylation [IDA]
- exosomal secretion [IDA]
- positive regulation of transcription from RNA polymerase II promoter [IDA]
- protein deneddylation [IMP]
- protein deubiquitination [IDA]
- regulation of JNK cascade [IDA]
- transcription from RNA polymerase II promoter [TAS]
- translation [TAS]
- translational initiation [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
FOXM1
Gene Ontology Biological Process
- DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator [IMP]
- G2/M transition of mitotic cell cycle [IDA, TAS]
- cell cycle [TAS]
- mitotic cell cycle [TAS]
- negative regulation of cell aging [IMP]
- negative regulation of stress-activated MAPK cascade [IMP]
- negative regulation of transcription from RNA polymerase II promoter [IMP]
- negative regulation of transcription, DNA-templated [IMP]
- positive regulation of cell proliferation [IMP]
- positive regulation of double-strand break repair [IMP]
- positive regulation of transcription from RNA polymerase II promoter [IDA, IMP]
- positive regulation of transcription, DNA-templated [IMP]
- regulation of Ras protein signal transduction [IMP]
- regulation of cell cycle [TAS]
- regulation of cell cycle arrest [IMP]
- regulation of cell growth [TAS]
- regulation of cell proliferation [NAS]
- regulation of reactive oxygen species metabolic process [IMP]
- regulation of transcription, DNA-templated [IDA, TAS]
- transcription from RNA polymerase II promoter [IBA, IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- cytoplasm [IDA]
- nucleoplasm [IDA, TAS]
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
CSN5 promotes the invasion and metastasis of pancreatic cancer by stabilization of FOXM1.
COP9 signalosome subunit 5 (CSN5) has been involved in the progression of diverse human cancers. MMP2 plays an important role in the metastasis of cancer cells. However, the roles and relationship of in pancreatic cancer (PC) is still unknown. Here, our data shown that both CSN5 and MMP2 were significantly upregulated in PC compared with the corresponding adjacent tissues, where ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID